DSpace Repository

Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos

Show simple item record

dc.contributor.author Fuentes, Macarena
dc.contributor.author Pulgar, Iván
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Bortolini, María-Cátira
dc.contributor.author Canizales-Quinteros, Samuel
dc.contributor.author Bedoya, Gabriel
dc.contributor.author González-José, Rolando
dc.contributor.author Ruiz-Linares, Andrés
dc.contributor.author Rothhammer, Francisco
dc.date.accessioned 2020-06-10T18:12:21Z
dc.date.available 2020-06-10T18:12:21Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8124
dc.description.abstract Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP's) which exhibit substantially different frequencies between Amerindian populations (ancestryinformative markers or AIM's), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0.45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a first approximation to determine genetic ancestry. en_US
dc.language.iso eng
dc.language.iso spa
dc.publisher Sociedad Médica de Santiago
dc.relation.ispartofseries Revista Médica de Chile
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject African Continental Ancestry Group en_US
dc.subject American Indian en_US
dc.subject American native continental ancestry group en_US
dc.subject American Native Continental Ancestry Group en_US
dc.subject Black person en_US
dc.subject Caucasian en_US
dc.subject Chile en_US
dc.subject ethnology en_US
dc.subject European Continental Ancestry Group en_US
dc.subject gene frequency en_US
dc.subject Gene Frequency en_US
dc.subject genetics en_US
dc.subject genotype en_US
dc.subject Genotype en_US
dc.subject human en_US
dc.subject Humans en_US
dc.subject Indians en_US
dc.subject phylogeography en_US
dc.subject Phylogeography en_US
dc.subject Polymorphism, Single Nucleotide en_US
dc.subject single nucleotide polymorphism en_US
dc.subject South American en_US
dc.title Geografía génica de Chile. Distribución regional de los aportes genéticos americanos, europeos y africanos es_PE
dc.title.alternative Gene geography of Chile Regional distribution of American, European and African genetic contributions en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4067/S0034-98872014000300001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 0717-6163

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


My Account