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Beyond birth-weight: early growth and adolescent blood pressure in a Peruvian population

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dc.contributor.author Sterling, Robie
dc.contributor.author Checkley, William
dc.contributor.author Gilman, Robert H.
dc.contributor.author Cabrera, Lilia
dc.contributor.author Sterling, Charles R.
dc.contributor.author Bern, Caryn
dc.contributor.author Miranda, J. Jaime
dc.date.accessioned 2020-06-10T18:12:21Z
dc.date.available 2020-06-10T18:12:21Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/8127
dc.description.abstract Background. Longitudinal investigations into the origins of adult essential hypertension have found elevated blood pressure in children to accurately track into adulthood, however the direct causes of essential hypertension in adolescence and adulthood remains unclear. Methods. We revisited 152 Peruvian adolescents from a birth cohort tracked from 0 to 30 months of age, and evaluated growth via monthly anthropometric measurements between 1995 and 1998, and obtained anthropometric and blood pressure measurements 11-14 years later. We used multivariable regression models to study the effects of infantile and childhood growth trends on blood pressure and central obesity in early adolescence. Results. In regression models adjusted for interim changes in weight and height, each 0.1 SD increase in weight for length from 0 to 5 months of age, and 1 SD increase from 6 to 30 months of age, was associated with decreased adolescent systolic blood pressure by 1.3 mm Hg (95% CI -2.4 to -0.1) and 2.5 mm Hg (95% CI -4.9 to 0.0), and decreased waist circumference by 0.6 (95% CI -1.1 to 0.0) and 1.2 cm (95% CI -2.3 to -0.1), respectively. Growth in infancy and early childhood was not significantly associated with adolescent waist-to-hip ratio. Conclusions. Rapid compensatory growth in early life has been posited to increase the risk of long-term cardiovascular morbidities such that nutritional interventions may do more harm than good. However, we found increased weight growth during infancy and early childhood to be associated with decreased systolic blood pressure and central adiposity in adolescence. en_US
dc.language.iso eng
dc.publisher PeerJ
dc.relation.ispartof urn:issn:2167-8359
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Blood pressure en_US
dc.subject Child development en_US
dc.subject Cohort studies en_US
dc.subject Developmental origins en_US
dc.subject Growth and development en_US
dc.subject Hypertension en_US
dc.subject Lifecourse en_US
dc.subject Obesity en_US
dc.subject Peru en_US
dc.title Beyond birth-weight: early growth and adolescent blood pressure in a Peruvian population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.7717/peerj.381
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.01.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04


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