Universidad Peruana Cayetano Heredia
Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
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| dc.contributor.author | Abascal, Estefanía | |
| dc.contributor.author | Herranz, Marta | |
| dc.contributor.author | Acosta, Fermín | |
| dc.contributor.author | Agapito, Juan | |
| dc.contributor.author | Cabibbe, Andrea M. | |
| dc.contributor.author | Monteserin, Johana | |
| dc.contributor.author | Ruiz Serrano, María Jesús | |
| dc.contributor.author | Gijón, Paloma | |
| dc.contributor.author | Fernández-González, Francisco | |
| dc.contributor.author | Lozano, Nuria | |
| dc.contributor.author | Chiner-Oms, Álvaro | |
| dc.contributor.author | Cáceres Nakiche, Tatiana | |
| dc.contributor.author | Pintado, Pilar Gómez | |
| dc.contributor.author | Acín, Enrique | |
| dc.contributor.author | Valencia, Eddy | |
| dc.contributor.author | Muñoz, Patricia | |
| dc.contributor.author | Comas, Iñaki | |
| dc.contributor.author | Cirillo, Daniela M. | |
| dc.contributor.author | Ritacco, Viviana | |
| dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
| dc.contributor.author | García de Viedma, Darío | |
| dc.date.accessioned | 2020-07-14T00:00:51Z | |
| dc.date.available | 2020-07-14T00:00:51Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8211 | |
| dc.description.abstract | It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection. | en_US |
| dc.description.sponsorship | Este trabajo fue financiado por FONDECYT [número de contrato PER-2012-ELAC2015/T08-0664]. | es_PE |
| dc.language.iso | eng | |
| dc.publisher | Springer Nature | |
| dc.relation.ispartofseries | Scientific Reports | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Clinical microbiology | en_US |
| dc.subject | Epidemiology | en_US |
| dc.title | Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1038/s41598-020-59373-w | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.06.01 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.09 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.07 | |
| dc.relation.issn | 2045-2322 |
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