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Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

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dc.contributor.author Abascal, Estefanía
dc.contributor.author Herranz, Marta
dc.contributor.author Acosta, Fermín
dc.contributor.author Agapito, Juan
dc.contributor.author Cabibbe, Andrea M.
dc.contributor.author Monteserin, Johana
dc.contributor.author Ruiz Serrano, María Jesús
dc.contributor.author Gijón, Paloma
dc.contributor.author Fernández-González, Francisco
dc.contributor.author Lozano, Nuria
dc.contributor.author Chiner-Oms, Álvaro
dc.contributor.author Cáceres Nakiche, Tatiana
dc.contributor.author Pintado, Pilar Gómez
dc.contributor.author Acín, Enrique
dc.contributor.author Valencia, Eddy
dc.contributor.author Muñoz, Patricia
dc.contributor.author Comas, Iñaki
dc.contributor.author Cirillo, Daniela M.
dc.contributor.author Ritacco, Viviana
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author García de Viedma, Darío
dc.date.accessioned 2020-07-14T00:00:51Z
dc.date.available 2020-07-14T00:00:51Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8211
dc.description.abstract It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Scientific Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Clinical microbiology en_US
dc.subject Epidemiology en_US
dc.title Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41598-020-59373-w
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 2045-2322

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