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Severe COVID-19 during pregnancy and possible vertical transmission

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dc.contributor.author Alzamora, Maria Claudia
dc.contributor.author Paredes, Tania
dc.contributor.author Caceres, David
dc.contributor.author Webb, Camille M.
dc.contributor.author Valdez, Luis M.
dc.contributor.author La Rosa, Mauricio
dc.date.accessioned 2020-07-14T00:00:54Z
dc.date.available 2020-07-14T00:00:54Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8222
dc.description.abstract There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. en_US
dc.language.iso eng
dc.publisher Thieme Publishing Group
dc.relation.ispartof urn:issn:2157-7005
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject coronavirus en_US
dc.subject neonate en_US
dc.subject pregnancy en_US
dc.title Severe COVID-19 during pregnancy and possible vertical transmission en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1055/s-0040-1710050


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