Severe COVID-19 during pregnancy and possible vertical transmission

Valdez, Luis M.; La Rosa, Mauricio; Webb, Camille M.; Paredes, Tania; Alzamora, Maria Claudia; Caceres, David

dc.contributor.author	Alzamora, Maria Claudia
dc.contributor.author	Paredes, Tania
dc.contributor.author	Caceres, David
dc.contributor.author	Webb, Camille M.
dc.contributor.author	Valdez, Luis M.
dc.contributor.author	La Rosa, Mauricio
dc.date.accessioned	2020-07-14T00:00:54Z
dc.date.available	2020-07-14T00:00:54Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8222
dc.description.abstract	There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons.	en_US
dc.language.iso	eng
dc.publisher	Thieme Gruppe
dc.relation.ispartofseries	AJP Reports
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	COVID-19	en_US
dc.subject	coronavirus	en_US
dc.subject	neonate	en_US
dc.subject	pregnancy	en_US
dc.title	Severe COVID-19 during pregnancy and possible vertical transmission	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1055/s-0040-1710050
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.03
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.02
dc.relation.issn	2157-7005