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Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity

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dc.contributor.author Ambulay, Johnny P.
dc.contributor.author Rojas, Percy A.
dc.contributor.author Timoteo, Olga S.
dc.contributor.author Barreto, Teresa
dc.contributor.author Colarossi, Ana
dc.date.accessioned 2020-07-14T00:00:54Z
dc.date.available 2020-07-14T00:00:54Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8223
dc.description.abstract Sacha Inchi (Plukenetia huayllabambana), an oleoleguminosae with a high content ω-3, could help normalize alterations of obesity. We evaluated the effect of emulsion of Sacha Inchi (SI) oil on the lipid profile, oxidative stress and inflammation in serum and liver tissue of obesity-induced rats. Five groups induced to obesity by high-fat diet were analyzed. One group without treatment, two groups with the emulsion of SI oil (OSI1:0.25 ω-3/day, OSI2:0.5 ω-3/day), one group with atorvastatin and one group with atorvastatin plus the emulsion of SI oil. The treated groups lowered the values of total cholesterol, triglycerides, and LDLc, and increased HDLc. The lipid and protein oxidation marker, IL-6 and leptin decreased in serum, as well as TNF-α hepatic. In contrast, serum adiponectin, antioxidant capacity, and liver catalase activity increased in the OSI2 group. Therefore, the emulsion of SI oil normalizes the lipid profile and decreases oxidative stress and inflammation in an obesity model. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1756-4646
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Inflammation en_US
dc.subject Lipid profile en_US
dc.subject Obesity en_US
dc.subject Oxidative stress en_US
dc.subject Sacha Inchi en_US
dc.title Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jff.2019.103631
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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