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Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru

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dc.contributor.author Berry, Alexander S. F.
dc.contributor.author Salazar-Sánchez, Renzo
dc.contributor.author Castillo-Neyra, Ricardo
dc.contributor.author Borrini-Mayorí, Katty
dc.contributor.author Arevalo-Nieto, Claudia
dc.contributor.author Chipana-Ramos, Claudia
dc.contributor.author Vargas-Maquera, Melina
dc.contributor.author Ancca-Juarez, Jenny
dc.contributor.author Náquira-Velarde, César
dc.contributor.author Levy, Michael Z.
dc.contributor.author Brisson, Dustin
dc.date.accessioned 2020-07-14T00:00:57Z
dc.date.available 2020-07-14T00:00:57Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8235
dc.description.abstract Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks-parasites in the same block tend to be very closely related-but no population structure among blocks within districts-parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartof urn:issn:1935-2735
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject Peru/epidemiology en_US
dc.subject Genotype en_US
dc.subject Disease Transmission, Infectious en_US
dc.subject Phylogeny en_US
dc.subject Animals, Domestic/parasitology en_US
dc.subject Chagas Disease/epidemiology/parasitology/transmission en_US
dc.subject Disease Vectors en_US
dc.subject Molecular Epidemiology en_US
dc.subject Trypanosoma cruzi/classification/genetics/isolation & purification en_US
dc.title Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0007910
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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