Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru

Castillo Neyra, Ricardo; Borrini-Mayorí, Katty; Levy, Michael Z.; Brisson, Dustin; Salazar Sánchez, Renzo Sadath; Chipana-Ramos, Claudia; Arevalo Nieto, Claudia Rebeca; Vargas-Maquera, Melina; Berry, Alexander S. F.; Naquira Velarde, Cesar Gabriel; Ancca-Juarez, Jenny

dc.contributor.author	Berry, Alexander S. F.
dc.contributor.author	Salazar Sánchez, Renzo Sadath
dc.contributor.author	Castillo Neyra, Ricardo
dc.contributor.author	Borrini-Mayorí, Katty
dc.contributor.author	Arevalo Nieto, Claudia Rebeca
dc.contributor.author	Chipana-Ramos, Claudia
dc.contributor.author	Vargas-Maquera, Melina
dc.contributor.author	Ancca-Juarez, Jenny
dc.contributor.author	Naquira Velarde, Cesar Gabriel
dc.contributor.author	Levy, Michael Z.
dc.contributor.author	Brisson, Dustin
dc.date.accessioned	2020-07-14T00:00:57Z
dc.date.available	2020-07-14T00:00:57Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8235
dc.description.abstract	Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks-parasites in the same block tend to be very closely related-but no population structure among blocks within districts-parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal.	en_US
dc.language.iso	eng
dc.publisher	Public Library of Science
dc.relation.ispartofseries	PLoS Neglected Tropical Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Humans	en_US
dc.subject	Animals	en_US
dc.subject	Peru/epidemiology	en_US
dc.subject	Genotype	en_US
dc.subject	Disease Transmission, Infectious	en_US
dc.subject	Phylogeny	en_US
dc.subject	Animals, Domestic/parasitology	en_US
dc.subject	Chagas Disease/epidemiology/parasitology/transmission	en_US
dc.subject	Disease Vectors	en_US
dc.subject	Molecular Epidemiology	en_US
dc.subject	Trypanosoma cruzi/classification/genetics/isolation & purification	en_US
dc.title	Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1371/journal.pntd.0007910
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1935-2735