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ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in chileans

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dc.contributor.author Boekstegers, Felix
dc.contributor.author Marcelain, Katherine
dc.contributor.author Barahona Ponce, Carol
dc.contributor.author Baez Benavides, Pablo F.
dc.contributor.author Müller, Bettina
dc.contributor.author de Toro, Gonzalo
dc.contributor.author Retamales, Javier
dc.contributor.author Barajas, Olga
dc.contributor.author Ahumada, Monica
dc.contributor.author Morales, Erik
dc.contributor.author Rojas, Armando
dc.contributor.author Sanhueza, Verónica
dc.contributor.author Loader, Denisse
dc.contributor.author Rivera, María Teresa
dc.contributor.author Gutiérrez, Lorena
dc.contributor.author Bernal, Giuliano
dc.contributor.author Ortega, Alejandro
dc.contributor.author Montalvo, Domingo
dc.contributor.author Portiño, Sergio
dc.contributor.author Bertrán, Maria Enriqueta
dc.contributor.author Gabler, Fernando
dc.contributor.author Spencer, Loreto
dc.contributor.author Olloquequi, Jordi
dc.contributor.author González Silos, Rosa
dc.contributor.author Fischer, Christine
dc.contributor.author Scherer, Dominique
dc.contributor.author Jenab, Mazda
dc.contributor.author Aleksandrova, Krasimira
dc.contributor.author Katzke, Verena
dc.contributor.author Weiderpass, Elisabete
dc.contributor.author Moradi, Tahereh
dc.contributor.author Fischer, Krista
dc.contributor.author Bossers, Willem
dc.contributor.author Brenner, Hermann
dc.contributor.author Hveem, Kristian
dc.contributor.author Eklund, Niina
dc.contributor.author Völker, Uwe
dc.contributor.author Waldenberger, Melanie
dc.contributor.author Fuentes Guajardo, Macarena
dc.contributor.author Gonzalez-Jose, Rolando
dc.contributor.author Bedoya, Gabriel
dc.contributor.author Bortolini, Maria C.
dc.contributor.author Canizales, Samuel
dc.contributor.author Gallo, Carla
dc.contributor.author Ruiz Linares, Andres
dc.contributor.author Rothhammer, Francisco
dc.contributor.author Lorenzo Bermejo, Justo
dc.date.accessioned 2020-07-14T00:00:57Z
dc.date.available 2020-07-14T00:00:57Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8237
dc.description.abstract BACKGROUND: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. METHODS: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. RESULTS: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. CONCLUSION: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1877-783X
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cancer epidemiology en_US
dc.subject Gallbladder cancer en_US
dc.subject Native American ancestry en_US
dc.subject Population-specific risk marker en_US
dc.title ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in chileans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.canep.2019.101643
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.21

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