Universidad Peruana Cayetano Heredia

Global REACH: assessment of brady-arrhythmias in andeans and lowlanders during apnea at 4330 m

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dc.contributor.author Busch, Stephen A.
dc.contributor.author van Diepen, Sean
dc.contributor.author Steele, Andrew R.
dc.contributor.author Meah, Victoria L.
dc.contributor.author Simpson, Lydia L.
dc.contributor.author Figueroa-Mujíca, Rómulo J.
dc.contributor.author Vizcardo-Galindo, Gustavo
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Tymko, Michael M.
dc.contributor.author Ainslie, Philip N.
dc.contributor.author Moore, Jonathan P.
dc.contributor.author Stembridge, Mike
dc.contributor.author Steinback, Craig D.
dc.date.accessioned 2020-07-14T00:00:59Z
dc.date.available 2020-07-14T00:00:59Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/8243
dc.description.abstract Background: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (i.e., Nepalese Sherpa) may have arrhythmias resistant adaptations that prevent arrhythmogenesis at altitude, though this has not been documented in other High altitude groups, including those diagnosed with chronic mountain sickness (CMS). We investigated whether healthy (CMS-) and CMS afflicted (CMS +) Andeans exhibit cardiac arrhythmias under acute apneic stress at altitude. Methods and Results: Electrocardiograms (lead II) were collected in CMS- (N = 9), CMS + (N = 8), and Lowlanders (N = 13) following several days at 4330 m (Cerro de Pasco, Peru). ECG rhythm and HR were assessed at both rest and during maximal volitional apnea. Both CMS- and CMS + had similar basal HR (69 ± 8 beats/min vs. 62 ± 11 beats/min), while basal HR was higher in Lowlanders (77 ± 18 beats/min; P < 0.05 versus CMS +). Apnea elicited significant bradycardia (nadir −32 ± 15 beats/min; P < 0.01) and the development of arrhythmias in 8/13 Lowlanders (junctional rhythm, 3° atrio-ventricular block, sinus pause). HR was preserved was prior to volitional breakpoint in both CMS- (nadir −6 ± 1 beat/min) and CMS + (1 ± 12 beats/min), with 2/17 Andeans developing arrhythmias (1 CMS+ and 1 CMS-; both Premature atrial contraction) prior to breakpoint. Conclusion: Andeans showed an absence of arrhythmias and preserved HR response to volitional apnea at altitude, demonstrating that potential cardio-resistant adaptations to arrhythmogenesis exist across permanent HA populations. Acclimatized Lowlanders have further demonstrated an increased prevalence of arrhythmias at altitude. en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Andean en_US
dc.subject arrhythmia en_US
dc.subject cardiac en_US
dc.subject chronic mountain sickness en_US
dc.subject electrophysiology en_US
dc.subject high altitude physiology en_US
dc.subject hypoxia en_US
dc.title Global REACH: assessment of brady-arrhythmias in andeans and lowlanders during apnea at 4330 m en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fphys.2019.01603
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn 1664-042X


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