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Frequency and determinant factors for calcification in neurocysticercosis

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dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Arroyo Hurtado, Gianfranco
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Soto Becerra, Percy
dc.contributor.author Gonzales, Isidro
dc.contributor.author Saavedra Pastor, Herbert
dc.contributor.author Pretell, E. Javier
dc.contributor.author Nash, Theodore E.
dc.contributor.author O'Neal, Seth E.
dc.contributor.author Del Brutto, Oscar H.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2020-07-14T00:00:59Z
dc.date.available 2020-07-14T00:00:59Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/8245
dc.description.abstract BACKGROUND: Neurocysticercosis is a major cause of acquired epilepsy. Larval cysts in the human brain eventually resolve and either disappear or leave a calcification that is associated with seizures. In this study, we assessed the proportion of calcification in parenchymal neurocysticercosis and risk factors associated with calcification. METHODS: Data for 220 patients with parenchymal NCC from 3 trials of antiparasitic treatment were assessed to determine what proportion of the cysts that resolved 6 months after treatment ended up in a residual calcification at 1 year. Also, we evaluated the risk factors associated with calcification. RESULTS: The overall proportion of calcification was 38% (188/497 cysts, from 147 patients). Predictors for calcification at the cyst level were cysts larger than 14 mm (risk ratio [RR], 1.34; 95% confidence interval [CI], 1.02-1.75) and cysts with edema at baseline (RR, 1.39; 95% CI, 1.05-1.85). At the patient level, having had more than 24 months with seizures (RR, 1.25; 95% CI, 1.08-1.46), mild antibody response (RR, 1.14; 95% CI, 1.002-1.27), increased dose albendazole regime (RR, 1.26; 95% CI, 1.14-1.39), lower doses of dexamethasone (RR, 1.36; 95% CI, 1.02-1.81), not receiving early antiparasitic retreatment (RR, 1.45; 95% CI, 1.08-1.93), or complete cure (RR, 1.48; 95% CI, 1.29-1.71) were associated with a increased risk of calcification. CONCLUSIONS: Approximately 38% of parenchymal cysts calcify after antiparasitic treatment. Some factors associated with calcification are modifiable and may be considered to decrease or avoid calcification, potentially decreasing the risk for seizure relapses en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Perú en_US
dc.subject Cysticercosis en_US
dc.subject Taenia solium en_US
dc.subject calcification en_US
dc.subject risk factors en_US
dc.title Frequency and determinant factors for calcification in neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/ciaa784
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


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