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Design and rationale of the HAPIN study: a multicountry randomized controlled trial to assess the effect of liquefied petroleum gas stove and continuous fuel distribution

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dc.contributor.author Clasen, Thomas
dc.contributor.author Checkley, William
dc.contributor.author Peel, Jennifer L.
dc.contributor.author Balakrishnan, Kalpana
dc.contributor.author McCracken, John P.
dc.contributor.author Rosa, Ghislaine
dc.contributor.author Thompson, Lisa M.
dc.contributor.author Barr, Dana Boyd
dc.contributor.author Clark, Maggie L.
dc.contributor.author Johnson, Michael A.
dc.contributor.author Waller, Lance A.
dc.contributor.author Jaacks, Lindsay M.
dc.contributor.author Steenland, Kyle
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Chang, Howard H.
dc.contributor.author Kim, Dong-Yun
dc.contributor.author McCollum, Eric D.
dc.contributor.author Davila-Roman, Victor G.
dc.contributor.author Papageorghiou, Aris
dc.contributor.author Rosenthal, Joshua P.
dc.contributor.author HAPIN Investigators
dc.date.accessioned 2020-07-14T00:01:05Z
dc.date.available 2020-07-14T00:01:05Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8266
dc.description.abstract BACKGROUND: Globally, nearly 3 billion people rely on solid fuels for cooking and heating, the vast majority residing in low-and middle-income countries (LMICs). The resulting household air pollution (HAP) is a leading environmental risk factor, accounting for an estimated 1.6 million premature deaths annually. Previous interventions of cleaner stoves have often failed to reduce exposure to levels that produce meaningful health improvements. There have been no multicountry field trials with liquefied petroleum gas (LPG) stoves, likely the cleanest scalable intervention. OBJECTIVE: This paper describes the design and methods of an ongoing randomized controlled trial (RCT) of LPG stove and fuel distribution in 3,200 households in 4 LMICs (India, Guatemala, Peru, and Rwanda). METHODS: We are enrolling 800 pregnant women at each of the 4 international research centers from households using biomass fuels. We are randomly assigning households to receive LPG stoves, an 18-month supply of free LPG, and behavioral reinforcements to the control arm. The mother is being followed along with her child until the child is 1 year old. Older adult women (40 to <80 years of age) living in the same households are also enrolled and followed during the same period. Primary health outcomes are low birth weight, severe pneumonia incidence, stunting in the child, and high blood pressure (BP) in the older adult woman. Secondary health outcomes are also being assessed. We are assessing stove and fuel use, conducting repeated personal and kitchen exposure assessments of fine particulate matter with aerodynamic diameter ≤2:5 lm (PM2:5), carbon monoxide (CO), and black carbon (BC), and collecting dried blood spots (DBS) and urinary samples for biomarker analysis. Enrollment and data collection began in May 2018 and will continue through August 2021. The trial is registered with ClinicalTrials.gov (NCT02944682). CONCLUSIONS: This study will provide evidence to inform national and global policies on scaling up LPG stove use among vulnerable populations. en_US
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof urn:issn:1552-9924
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Design and rationale of the HAPIN study: a multicountry randomized controlled trial to assess the effect of liquefied petroleum gas stove and continuous fuel distribution en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1289/EHP6407
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05

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