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Secretory immunoglobulin A (sIgA) in saliva versus virulence proteins of enteropathogenic Escherichia coli (EPEC) in ill and colonized children

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dc.contributor.author Durand Vara, David Percy
dc.contributor.author Alvarez, Daniela
dc.contributor.author Diaz, David
dc.contributor.author Mercado, Erik
dc.contributor.author Ruiz, Joaquim
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2020-07-14T00:01:08Z
dc.date.available 2020-07-14T00:01:08Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8281
dc.description.abstract INTRODUCTION: We evaluated the presence of sIgA in saliva, versus Escherichia coli secreted proteins (Esp) related to the type III secretion system (T3SS), and its semi-quantitative concentration in children under 2 years-old (no longer breastfed) who were previously colonized or infected with enteropathogenic E. coli (EPEC). METHODS: We analyzed the presence of sIgA in 40 children, who previously had positive cultures for EPEC associated (n=17) or not associated (n=23) with diarrhea, using the Western Blot technique versus E. coli secreted proteins: EspABCD. A semi-quantitative measurement of the reaction for each protein was made by its density peaks (OD). RESULTS: We found sIgA versus all or some EspABCD proteins in both groups. However, the ill patients had higher concentrations of these antibodies than colonized patients. DISCUSSION: The presence of sIgA in saliva could reflect an intestinal immune response and their levels could be related to a greater exposure and/or bacterial load. en_US
dc.description.abstract Introducción: Evaluamos la presencia de inmunoglobulina secretoria A (sIgA) frente a proteínas secretadas por E. coli (Esp) relacionadas con el sistema de secreción tipo III (T3SS) en saliva, y su concentración semicuantitativa en niños menores de 2 años (no lactantes) colonizados o infectados previamente con E. coli enteropatógena (EPEC). Métodos: Analizamos la presencia de sIgA en 40 niños con cultivos positivos previos para EPEC asociados (n = 17) o no (n = 23) con diarrea, mediante la técnica de Western-blot frente a las proteínas secretadas por E. coli (EspABCD), realizando mediciones semicuantitativas de la reacción de cada proteína mediante sus picos de densidad (OD). Resultados: Ambos grupos presentaron sIgA frente a las proteínas EspABCD, aunque los pacientes enfermos presentaron mayores concentraciones de estos anticuerpos que los colonizados. Discusión: La presencia de sIgA en la saliva podría reflejar una respuesta inmune intestinal y sus niveles podrían estar relacionados con una mayor exposición y/o carga bacteriana. es_PE
dc.language.iso eng
dc.language.iso spa
dc.publisher Elsevier
dc.relation.ispartofseries Enfermedades Infecciosas y Microbiologia Clinica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Children en_US
dc.subject Inmunoglobulina A secretoria en saliva en_US
dc.subject Ninos en_US
dc.subject Proteinas de virulencia en_US
dc.subject Secretory immunoglobulin A in saliva en_US
dc.subject Sistema de secrecion tipo III en_US
dc.subject Type III secretion system en_US
dc.subject Virulence proteins en_US
dc.title Secretory immunoglobulin A (sIgA) in saliva versus virulence proteins of enteropathogenic Escherichia coli (EPEC) in ill and colonized children en_US
dc.title.alternative Inmunoglobulina A secretoria en saliva frente a proteínas de virulencia de Escherichia coli enteropatogénica en niños enfermos y colonizados es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.eimc.2019.08.006
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1578-1852


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