Universidad Peruana Cayetano Heredia

Patients’ preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study

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dc.contributor.author Erber, Astrid C.
dc.contributor.author Arana, Byron
dc.contributor.author Ben Salah, Afif
dc.contributor.author Bennis, Issam
dc.contributor.author Boukthir, Aicha
dc.contributor.author Castro Noriega, María Del Mar
dc.contributor.author Cissé, Mamoudou
dc.contributor.author Cota, Gláucia Fernandes
dc.contributor.author Handjani, Farhad
dc.contributor.author López-Carvajal, Liliana
dc.contributor.author Marsh, Kevin
dc.contributor.author Medina, Dalila Martínez
dc.contributor.author Plugge, Emma
dc.contributor.author Lang, Trudie
dc.contributor.author Olliaro, Piero
dc.date.accessioned 2020-07-14T00:01:09Z
dc.date.available 2020-07-14T00:01:09Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8286
dc.description.abstract BACKGROUND: Cutaneous leishmaniasis (CL) is a disease that often affects exposed skin areas and may heal leaving lifelong scars. Patients' expectations from treatment are rarely considered in drug development for CL. An initiative aiming to address shortcomings in clinical trial design and conduct for CL treatments involving the researchers' community is on-going. This manuscript presents patient-preferred outcomes for CL and an assessment on how to consider these in the conduct of future trials. METHODOLOGY/PRINCIPAL FINDINGS: We report preferred treatment outcomes by 74 patients with confirmed CL in endemic regions of Brazil, Burkina Faso, Colombia, Iran, Morocco, Peru and Tunisia during individual in-depth interviews. Beyond outcomes customarily considered in trials (such as lesion appearance and adverse events), patients talked about a large number of outcomes related to quality of life, such as pain, scar formation, and others affecting their work and daily activities. They also reported fears around getting rid of the parasite, disease recurrence, and possible sequelae. CONCLUSIONS/SIGNIFICANCE: The study results provide a rich insight into important outcomes for CL treatments, as well as related topics, from the perspective of a diverse patient population. Among the outcomes identified, we argue that those related to quality of life as well as recurrence should be included to a greater extent for assessment in clinical trials, and discuss the suitability of measurement instruments such as the Dermatology Quality of Life Index (DLQI). Interviews also point out the potential need to address concerns related to parasitological cure or scar formation, such as social stigmatization and disability. In addition, patients should be given information in order to clarify reported misconceptions. This study therefore suggests a methodology for consulting CL patients on outcomes as elements of clinical trial design, and how to incorporate these outcomes in trials. It also discusses how reported outcomes could be addressed in clinical care. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Data Collection en_US
dc.subject Qualitative Research en_US
dc.subject Quality of Life en_US
dc.subject Treatment Outcome en_US
dc.subject Patient Preference en_US
dc.subject Global Health en_US
dc.subject Antiprotozoal Agents/therapeutic use en_US
dc.subject Leishmaniasis, Cutaneous/drug therapy/pathology en_US
dc.title Patients’ preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0007996
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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