Taenia solium cysticercosis and its impact in neurological disease

García Lescano, Héctor Hugo; Gilman, Robert Hugh; Gonzalez Zariquiey, Armando Emiliano

dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author	Gilman, Robert Hugh
dc.date.accessioned	2020-07-14T00:01:11Z
dc.date.available	2020-07-14T00:01:11Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8293
dc.description.abstract	Taenia solium neurocysticercosis (NCC) is endemic in most of the world and contributes significantly to the burden of epilepsy and other neurological morbidity. Also present in developed countries because of immigration and travel, NCC is one of few diseases targeted for eradication. This paper reviews all aspects of its life cycle (taeniasis, porcine cysticercosis, human cysticercosis), with a focus on recent advances in its diagnosis, management, and control. Diagnosis of taeniasis is limited by poor availability of immunological or molecular assays. Diagnosis of NCC rests on neuroimaging findings, supported by serological assays. The treatment of NCC should be approached in the context of the particular type of infection (intra- or extraparenchymal; number, location, and stage of lesions) and has evolved toward combined symptomatic and antiparasitic management, with particular attention to modulating inflammation. Research on NCC and particularly the use of recently available genome data and animal models of infection should help to elucidate mechanisms of brain inflammation, damage, and epileptogenesis.	en_US
dc.language.iso	eng
dc.publisher	American Society for Microbiology
dc.relation.ispartofseries	Clinical Microbiology Reviews
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Peru	en_US
dc.subject	Taenia solium	en_US
dc.subject	cysticercosis	en_US
dc.subject	epilepsy	en_US
dc.subject	neurocysticercosis	en_US
dc.title	Taenia solium cysticercosis and its impact in neurological disease	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1128/CMR.00085-19
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.03
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn	1098-6618