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Origins, admixture dynamics and homogenization of the African gene pool in the Americas

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dc.contributor.author Gouveia, Mateus H.
dc.contributor.author Borda, Victor
dc.contributor.author Leal, Thiago P.
dc.contributor.author Moreira, Rennan G.
dc.contributor.author Bergen, Andrew W.
dc.contributor.author Kehdy, Fernanda S. G.
dc.contributor.author Alvim, Isabela
dc.contributor.author Aquino, Marla M.
dc.contributor.author Araujo, Gilderlanio S.
dc.contributor.author Araujo, Nathalia M.
dc.contributor.author Furlan, Vinicius
dc.contributor.author Liboredo, Raquel
dc.contributor.author Machado, Moara
dc.contributor.author Magalhaes, Wagner C. S.
dc.contributor.author Michelin, Lucas A.
dc.contributor.author Rodrigues, Maíra R.
dc.contributor.author Rodrigues-Soares, Fernanda
dc.contributor.author Sant Anna, Hanaisa P.
dc.contributor.author Santolalla Robles, Meddly Leslye
dc.contributor.author Scliar, Marília O.
dc.contributor.author Soares-Souza, Giordano
dc.contributor.author Zamudio, Roxana
dc.contributor.author Zolini, Camila
dc.contributor.author Bortolini, Maria Catira
dc.contributor.author Dean, Michael
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Guio, Heinner
dc.contributor.author Rocha, Jorge
dc.contributor.author Pereira, Alexandre C.
dc.contributor.author Barreto, Mauricio L.
dc.contributor.author Horta, Bernardo L.
dc.contributor.author Lima-Costa, Maria F.
dc.contributor.author Mbulaiteye, Sam M.
dc.contributor.author Chanock, Stephen J.
dc.contributor.author Tishkoff, Sarah A.
dc.contributor.author Yeager, Meredith
dc.contributor.author Tarazona-Santos, Eduardo
dc.date.accessioned 2020-07-14T00:01:12Z
dc.date.available 2020-07-14T00:01:12Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8297
dc.description.abstract The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to infer how different African groups contributed to North-, South-American and Caribbean populations, in the context of geographic and geopolitical factors, and compared genetic data with demographic history records of the Transatlantic Slave Trade. We observed that West-Central Africa and Western Africa-associated ancestry clusters are more prevalent in northern latitudes of the Americas, while the South/East Africa-associated ancestry cluster is more prevalent in southern latitudes of the Americas. This pattern results from geographic and geopolitical factors leading to population differentiation. However, there is a substantial decrease in the between-population differentiation of the African gene pool within the Americas, when compared to the regions of origin from Africa, underscoring the importance of historical factors favoring admixture between individuals with different African origins in the New World. This between-population homogenization in the Americas is consistent with the excess of West-Central Africa ancestry (the most prevalent in the Americas) in the United States and Southeast-Brazil, respect to historical-demography expectations. We also inferred that in most of the Americas, intercontinental admixture intensification occurred between 1,750 and 1,850, which correlates strongly with the peak of arrivals from Africa. This study contributes with a population genetics perspective to the ongoing social, cultural and political debate regarding ancestry, admixture and the mestizaje process in the Americas. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Molecular Biology and Evolution
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject controlled study en_US
dc.subject female en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject article en_US
dc.subject human experiment en_US
dc.subject adult en_US
dc.subject demography en_US
dc.subject Brazil en_US
dc.subject expectation en_US
dc.subject Caribbean (person) en_US
dc.subject Central Africa en_US
dc.subject gene pool en_US
dc.subject latitude en_US
dc.subject population differentiation en_US
dc.subject population genetics en_US
dc.subject slave trade en_US
dc.title Origins, admixture dynamics and homogenization of the African gene pool in the Americas en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/molbev/msaa033
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1537-1719

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