Universidad Peruana Cayetano Heredia

Exercise-induced increase in hemoglobin concentration at intermediate and high altitudes in Andeans, Tibetans and Han Chinese

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dc.contributor.author Gu, Wanjun
dc.contributor.author Wuren, Tana
dc.contributor.author Xu, Ian
dc.contributor.author Qin, Ga
dc.contributor.author Yan, Ma
dc.contributor.author Wei, Guan
dc.contributor.author Wagner, Harrieth
dc.contributor.author Macarlupu, Jose
dc.contributor.author Vicardo, Gustavo
dc.contributor.author Anza, Cecilia
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Ge, Ri-Li
dc.contributor.author Wagner, Peter
dc.contributor.author Simonson, Tatum
dc.date.accessioned 2020-07-14T00:01:12Z
dc.date.available 2020-07-14T00:01:12Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8299
dc.description.abstract An acute increase in hemoglobin concentration ([Hb]) up to 1.6 g/dL has been previously reported under the condition of exercise-induced hypoxemia in sea level individuals with COPD (Schagatay et.al 2015). Changes in [Hb] have been attributed to splenic contraction. To determine whether, and to what extent, [Hb] changes acutely in response to exercise in long-term residents at high altitude, we compared hemoglobin concentration at rest and during exercise in male Andean (n = 14; 4330 m) and Tibetan (n = 21; 4200 m) native highlanders, whose ancestors have resided for hundreds of generations at altitude, as well as Han Chinese (n = 9; 4200 m) high-altitude residents. In the latter two populations, we further examined male (Tibetan n = 10; Han n = 8) and female (Tibetan n = 9; Han n = 10) individuals both at a resident altitude of 2200 m and simulated altitude of 4200 m in a hypobaric chamber. We measured [Hb] at rest ([Hb]r), and peak exercise ([Hb]p), as well as blood oxygen saturation (SaO2), cardiac output (QT), VO2 and body mass index (BMI) and compared [Hb]p - [Hb]r, denoted as ?[Hb], for male Andeans at 4300 m, male Tibetans and Han Chinese resident at 4200 m, male and female Tibetans and Han Chinese resident at 2200 m and under simulated 4200 m. [Hb] significantly increased with exercise in all groups (P < 0.001 each) except for Han Chinese and Tibetan females at 4200 m. For male Andeans at 4300 m, ?[Hb] was 1.11 g/dL. For Han Chinese and Tibetans at 2200 m, ?[Hb] was 1.09 g/dL and 0.94 g/dL, respectively (males), and 1.17 g/dL and 1.01 g/dL respectively (females). For Han Chinese and Tibetans at 4200 m, ?[Hb] was also significant (p < 0.001) at 1.20 g/dL and 0.87 g/dL respectively in males, but in females the increases were not. No significant difference of ?[Hb] is observed across different ethnic groups regardless of sex at high altitude. The correlation between ?[Hb] and SaO2 at maximum exercise level is found to be positive in the Andeans (p = 0.007) and not detected in Tibetans or Han Chinese. In addition, there is no significant correlation found between ?[Hb] and BMI, [Hb]r, QTmax or VO2max. In conclusion, we observed an exercise-induced increased [Hb] among Andeans, Tibetans and Han Chinese at high altitude and Tibetans and Han Chinese only at intermediate altitude. Thus, measurement of [Hb] in-situ during hypoxia/exercise experiments are important to incorporate in studies of O2 transport. Furthermore, larger ?[Hb] can be potentially beneficial to maintaining higher oxygen saturation at high altitude during acute exercise. [Hb](g/dL) of Tibetans, Han Chinese and Andeans Ancestry Tibetans Han Chinese Andeans Exercise Level Rest Peak Rest Peak Rest Peak Male 15.4 ± 1.3 16.2 ± 1.2 16.7 ± 1.3 17.4 ± 1.1 2200 m Female 12.9 ± 1.8 13.5 ± 1.8 13.4 ± 1.2 14.1 ± 1.4 Male 15.1 ± 1.0 16.1 ± 1.4 16.2 ± 1.0 17.1 ± 0.9 17.3 ± 1.6 18.4 ± 1.7 4200 m Female 12.7 ± 1.5 13.1 ± 1.4 13.2 ± 1.3 13.8 ± 1.2 en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries FASEB Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Hemoglobin en_US
dc.subject high altitudes en_US
dc.subject Andeans en_US
dc.subject Tibetans en_US
dc.subject Han Chinese en_US
dc.title Exercise-induced increase in hemoglobin concentration at intermediate and high altitudes in Andeans, Tibetans and Han Chinese en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1096/fasebj.2020.34.s1.09609
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1530-6860


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