Universidad Peruana Cayetano Heredia

Regulatory T cell expansion resolves after effective strongyloidiasis treatment in subjects with HTLV-1 co-infection

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dc.contributor.author Hoces, Daniel
dc.contributor.author Barros, Nicolas
dc.contributor.author Woll, Fernando
dc.contributor.author Bauer, Allison
dc.contributor.author White, A. Clinton Jr
dc.contributor.author Montes Delgado, Martin
dc.date.accessioned 2020-07-14T00:01:16Z
dc.date.available 2020-07-14T00:01:16Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8306
dc.description.abstract BACKGROUND: Regulatory T-cells (Tregs) are increased in patients with HTLV-1/Strongyloides stercoralis co-infection, and they may modify otherwise protective antigen-specific cytokine production. We hypothesized that effective anti-helminthic treatment would decrease Tregs and restore antigen-specific cytokine responses. METHODS/RESULTS: We enrolled 19 patients with Strongyloides larvae in their stool by Baerman's test. Six were positive and 13 negative for antibody to HTLV-1 by ELISA, with positive tests confirmed by immunoblot. Before treatment, co-infected subjects had higher Tregs percentages and lower antigen-stimulated IL-5 levels compared to subjects with Strongyloides without HTLV-1. All patients were treated with ivermectin. After effective treatment, Tregs percentages decreased in patients with HTLV-1; however, antigen-specific IL-5 production remained blunted in co-infected subjects. CONCLUSION: These results suggest that treating strongyloidiasis infection decreases circulating Tregs, but antigen-specific cytokine remains altered. This may reflect blunting of sensitization by Tregs. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Parasitology International
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Article en_US
dc.subject controlled study en_US
dc.subject female en_US
dc.subject human en_US
dc.subject male en_US
dc.subject priority journal en_US
dc.subject adult en_US
dc.subject clinical article en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject mixed infection en_US
dc.subject immunoblotting en_US
dc.subject ivermectin en_US
dc.subject peripheral blood mononuclear cell en_US
dc.subject antigen presenting cell en_US
dc.subject antigen specificity en_US
dc.subject Belgium en_US
dc.subject cell expansion en_US
dc.subject cytokine production en_US
dc.subject cytokine response en_US
dc.subject eosinophil count en_US
dc.subject flow cytometry en_US
dc.subject HTLV-1 infection en_US
dc.subject interleukin 5 en_US
dc.subject intestine flora en_US
dc.subject regulatory T lymphocyte en_US
dc.subject strongyloidiasis en_US
dc.subject Western blotting en_US
dc.title Regulatory T cell expansion resolves after effective strongyloidiasis treatment in subjects with HTLV-1 co-infection en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.parint.2020.102092
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1873-0329


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