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Tear biomarkers and corneal sensitivity as an indicator of neuropathy in type 2 diabetes

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dc.contributor.author Iyengar, Meera F.
dc.contributor.author Soto, Luis F.
dc.contributor.author Requena, David
dc.contributor.author Ruiz-Alejos, Andrea O.
dc.contributor.author Huaylinos, Yvonne
dc.contributor.author Velasquez, Ricardo
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Gilman, Robert Hugh
dc.date.accessioned 2020-07-14T00:02:29Z
dc.date.available 2020-07-14T00:02:29Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8311
dc.description.abstract Aims: Explore potential of 31 tear biomarkers involved in screening for diabetic peripheral neuropathy (DPN). Assess the utility of aesthesiometry for measuring corneal damage in DPN and determine optimal cutoff point for detecting DPN. Methods: Screening test pilot study recruited 90 participants from a tertiary hospital in Lima, Peru. Participants were grouped by diabetes and neuropathy status. Tears collected on Schirmer strips, and proteins measured by both ELISA and multiplex-bead assay. Corneal sensitivity was measured by aesthesiometry, and DPN by vibration perception threshold testing. Results: There were 89 participants included in the analysis. The mean age was 55.7 ± 1.46, and 58.4% were female. MMP-9 and TGF-alpha concentrations were higher in participants with DPN versus diabetes alone, though not significant. Aesthesiometry was decreased in individuals with DPN when compared to participants with diabetes alone (p < 0.01) and normal controls (p < 0.01). Optimal cutoff point for aesthesiometry was found to be 5.8 cm, with 79% sensitivity and 75% specificity. Conclusions: Tears are an insufficient standalone tool for detecting DPN based on the biomarkers analyzed. Aesthesiometry is a simple, inexpensive, and accurate method to assess corneal damage associated with moderate-severe DPN, and its integration into screening practices has potential to improve detection of DPN in poor-resource settings. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Diabetes Research and Clinical Practice
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Diabetes en_US
dc.subject Aesthesiometry en_US
dc.subject Corneal neuropathy en_US
dc.subject Diabetic neuropathy en_US
dc.subject Tear biomarkers en_US
dc.subject Type 2 diabetes en_US
dc.title Tear biomarkers and corneal sensitivity as an indicator of neuropathy in type 2 diabetes en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.diabres.2020.108143
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1872-8227


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