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Multiplex Human Malaria Array: Quantifying Antigens for Malaria Rapid Diagnostics

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dc.contributor.author Jang, Ihn Kyung
dc.contributor.author Tyler, Abby
dc.contributor.author Lyman, Chris
dc.contributor.author Rek, John C.
dc.contributor.author Arinaitwe, Emmanuel
dc.contributor.author Adrama, Harriet
dc.contributor.author Murphy, Maxwell
dc.contributor.author Imwong, Mallika
dc.contributor.author Proux, Stephane
dc.contributor.author Haohankhunnatham, Warat
dc.contributor.author Barney, Rebecca
dc.contributor.author Rashid, Andrew
dc.contributor.author Kalnoky, Michael
dc.contributor.author Kahn, Maria
dc.contributor.author Golden, Allison
dc.contributor.author Nosten, François
dc.contributor.author Greenhouse, Bryan
dc.contributor.author Gamboa, Dionicia
dc.contributor.author Domingo, Gonzalo J.
dc.date.accessioned 2020-07-14T00:02:29Z
dc.date.available 2020-07-14T00:02:29Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8312
dc.description.abstract Malaria antigen detection through rapid diagnostic tests (RDTs) is widely used to diagnose malaria and estimate prevalence. To support more sensitive next-generation RDT development and screen asymptomatic malaria, we developed and evaluated the Q-Plex Human Malaria Array, which quantifies the antigens commonly used in RDTs-Plasmodium falciparum-specific histidine-rich protein 2 (HRP2), P. falciparum-specific lactate dehydrogenase (Pf LDH), P. vivax -specific LDH (Pv LDH), and Pan malaria lactate dehydrogenase (Pan LDH), and human C-reactive protein (CRP), a biomarker of severity in malaria. At threshold levels yielding 99.5% or more diagnostic specificity, diagnostic sensitivities against polymerase chain reaction-confirmed malaria for HRP2, Pf LDH, Pv LDH, and Pan LDH were 92.7%, 71.5%, 46.1%, and 83.8%, respectively. P. falciparum culture strains and samples from Peru indicated that HRP2 andPf LDH combined improves detection of P. falciparum parasites with hrp2 and hrp3 deletions. This array can be used for antigen-based malaria screening and detecting hrp2/3 deletion mutants of P. falciparum. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:0002-9637
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Multiplex Human Malaria Array: Quantifying Antigens for Malaria Rapid Diagnostics en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.19-0763
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE


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