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Evidence for the use of triage, respiratory isolation, and effective treatment to reduce the transmission of Mycobacterium tuberculosis in health care settings: a systematic review

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dc.contributor.author Karat, Aaron S.
dc.contributor.author Gregg, Meghann
dc.contributor.author Barton, Hannah E.
dc.contributor.author Calderon, Maria
dc.contributor.author Ellis, Jayne
dc.contributor.author Falconer, Jane
dc.contributor.author Govender, Indira
dc.contributor.author Harris, Rebecca C.
dc.contributor.author Tlali, Mpho
dc.contributor.author Moore, David A. J.
dc.contributor.author Fielding, Katherine L.
dc.date.accessioned 2020-07-14T00:02:29Z
dc.date.available 2020-07-14T00:02:29Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8313
dc.description.abstract Evidence is limited for infection prevention and control (IPC) measures reducing Mycobacterium tuberculosis (MTB) transmission in health facilities. This systematic review, one of seven commissioned by the World Health Organization to inform the 2019 update of global tuberculosis (TB) IPC guidelines, asked: do triage and/or isolation and/or effective treatment of TB disease reduce MTB transmission in health care settings? Of 25 included articles, 19 reported latent TB infection (LTBI) incidence in health care workers (HCWs; absolute risk reductions 1%-21%); five reported TB disease incidence in HCWs (no/slight [high TB burden] or moderate [low burden] reduction) and two in HIV-positive in-patients (6%-29% reduction). 23/25 studies implemented multiple IPC measures; effects of individual measures could not be disaggregated. Packages of IPC measures appeared to reduce MTB transmission, but evidence for effectiveness of triage, isolation, or effective treatment, alone or in combination, was indirect and low quality. Harmonising study designs and reporting frameworks will permit formal data syntheses and facilitate policymaking. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:1537-6591
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject health personnel en_US
dc.subject hiv seropositivity en_US
dc.subject mycobacterium tuberculosis en_US
dc.subject triage en_US
dc.subject tuberculosis en_US
dc.subject world health organization en_US
dc.subject guidelines en_US
dc.subject latent tuberculosis en_US
dc.subject infection prophylaxis en_US
dc.subject absolute risk reduction en_US
dc.subject treatment effectiveness en_US
dc.subject respiratory isolation en_US
dc.title Evidence for the use of triage, respiratory isolation, and effective treatment to reduce the transmission of Mycobacterium tuberculosis in health care settings: a systematic review en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/ciaa720
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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