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Reliable Serological Diagnostic Tests for Arboviruses: Feasible or Utopia?

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dc.contributor.author Kerkhof, Karen
dc.contributor.author Falconi-Agapito, Francesca
dc.contributor.author Van Esbroeck, Marjan
dc.contributor.author Talledo, Michael
dc.contributor.author Ariën, Kevin K.
dc.date.accessioned 2020-07-14T00:02:30Z
dc.date.available 2020-07-14T00:02:30Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8317
dc.description.abstract Infections with arthropod-bome viruses are increasing globally as a result of climate and demographic changes, global dispersion of insect vectors, and increased air travel. The similar symptomatology of arboviral diseases and the cocirculation of different arboviruses in Africa, Asia, and South America complicate diagnosis. Despite the high sensitivity and specificity of molecular diagnostic tests, their utility is limited to the short viremic phase of arbovirus infections, and therefore the diagnosis of infection is frequently missed in clinical practice. Conversely, the duration of antibody responses provides a wider window of opportunity, making diagnosis more dependent on IgM/IgG detection. This review discusses the issues underlying the low specificity of antibody-detection assays, and addresses the challenges and strategies for discovering more specific biomarkers to enable a more accurate diagnosis. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1878-4380
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject arbovirus en_US
dc.subject diagnostics en_US
dc.subject flavivirus en_US
dc.subject serology en_US
dc.subject specificity en_US
dc.title Reliable Serological Diagnostic Tests for Arboviruses: Feasible or Utopia? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.tim.2019.11.005
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.011


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