Reliable Serological Diagnostic Tests for Arboviruses: Feasible or Utopia?

Van Esbroeck, Marjan; Ariën, Kevin K.; Falconi-Agapito, Francesca; Talledo Albujar, Michael John; Kerkhof, Karen

dc.contributor.author	Kerkhof, Karen
dc.contributor.author	Falconi-Agapito, Francesca
dc.contributor.author	Van Esbroeck, Marjan
dc.contributor.author	Talledo Albujar, Michael John
dc.contributor.author	Ariën, Kevin K.
dc.date.accessioned	2020-07-14T00:02:30Z
dc.date.available	2020-07-14T00:02:30Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8317
dc.description.abstract	Infections with arthropod-bome viruses are increasing globally as a result of climate and demographic changes, global dispersion of insect vectors, and increased air travel. The similar symptomatology of arboviral diseases and the cocirculation of different arboviruses in Africa, Asia, and South America complicate diagnosis. Despite the high sensitivity and specificity of molecular diagnostic tests, their utility is limited to the short viremic phase of arbovirus infections, and therefore the diagnosis of infection is frequently missed in clinical practice. Conversely, the duration of antibody responses provides a wider window of opportunity, making diagnosis more dependent on IgM/IgG detection. This review discusses the issues underlying the low specificity of antibody-detection assays, and addresses the challenges and strategies for discovering more specific biomarkers to enable a more accurate diagnosis.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Trends in Microbiology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	arbovirus	en_US
dc.subject	diagnostics	en_US
dc.subject	flavivirus	en_US
dc.subject	serology	en_US
dc.subject	specificity	en_US
dc.title	Reliable Serological Diagnostic Tests for Arboviruses: Feasible or Utopia?	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.tim.2019.11.005
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.011
dc.relation.issn	1878-4380