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The application of cytokine expression assays to differentiate active from previously treated syphilis.

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dc.contributor.author Kojima, N.
dc.contributor.author Siebert, J. C.
dc.contributor.author Maecker, H.
dc.contributor.author Rosenberg-Hasson, Y.
dc.contributor.author León Sandoval, Segundo Ramos
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Konda, K. A.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, J. D.
dc.date.accessioned 2020-07-14T00:02:30Z
dc.date.available 2020-07-14T00:02:30Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8319
dc.description.abstract To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, BDNF and TNFB, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95%CI: 82%-100%) sensitive, and 45% (95%CI, 18%-75%) specific. Our decision tree differentiated between serum specimens of serofast participants with treated syphilis and active syphilis. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cytokine en_US
dc.subject tumor necrosis factors en_US
dc.subject syphilis en_US
dc.subject brain-derived neurotrophic factor en_US
dc.subject decision trees en_US
dc.subject serum specimen en_US
dc.title The application of cytokine expression assays to differentiate active from previously treated syphilis. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiaa127
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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