DSpace Repository

The application of cytokine expression assays to differentiate active from previously treated syphilis.

Show simple item record

dc.contributor.author Kojima, N.
dc.contributor.author Siebert, J. C.
dc.contributor.author Maecker, H.
dc.contributor.author Rosenberg-Hasson, Y.
dc.contributor.author Leon, S. R.
dc.contributor.author Vargas, S. K.
dc.contributor.author Konda, K. A.
dc.contributor.author Caceres, C. F.
dc.contributor.author Klausner, J. D.
dc.date.accessioned 2020-07-14T00:02:30Z
dc.date.available 2020-07-14T00:02:30Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8319
dc.description.abstract To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, BDNF and TNFB, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95%CI: 82%-100%) sensitive, and 45% (95%CI, 18%-75%) specific. Our decision tree differentiated between serum specimens of serofast participants with treated syphilis and active syphilis. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:1537-6613
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cytokine en_US
dc.subject tumor necrosis factors en_US
dc.subject syphilis en_US
dc.subject brain-derived neurotrophic factor en_US
dc.subject decision trees en_US
dc.subject serum specimen en_US
dc.title The application of cytokine expression assays to differentiate active from previously treated syphilis. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiaa127
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


My Account