Cough dynamics in adults receiving tuberculosis treatment

Coronel, Jorge; Naik, Nehal; Paz-Soldan Parlette, Valerie Andrea; Gilman, Robert Hugh; Gayoso, Oscar; Comina, Germán; Zimic-Peralta, Mirko Juan; Lee, Gwenyth O.; Oberhelman, Richard; Evans, Carlton Anthony William; Ticona, Eduardo; Hernandez-Cordova, Gustavo

dc.contributor.author	Lee, Gwenyth O.
dc.contributor.author	Comina, Germán
dc.contributor.author	Hernandez-Cordova, Gustavo
dc.contributor.author	Naik, Nehal
dc.contributor.author	Gayoso, Oscar
dc.contributor.author	Ticona, Eduardo
dc.contributor.author	Coronel, Jorge
dc.contributor.author	Evans, Carlton Anthony William
dc.contributor.author	Zimic-Peralta, Mirko Juan
dc.contributor.author	Paz-Soldan Parlette, Valerie Andrea
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Oberhelman, Richard
dc.date.accessioned	2020-07-14T00:02:31Z
dc.date.available	2020-07-14T00:02:31Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8325
dc.description.abstract	Cough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy. We conducted a prospective cohort of recently diagnosed ambulatory adult patients with pulmonary tuberculosis in two tertiary hospitals in Lima, Peru. Pre-treatment and five times during the first two months of treatment, a vibrometer was used to capture 4-hour recordings of involuntary cough. A total of 358 recordings from 69 participants were analyzed using a computer algorithm. Total time spent coughing (seconds per hour) was a better predictor of microbiologic indicators of disease severity and treatment response than the frequency of cough episodes or cough power. Patients with prior tuberculosis tended to cough more than patients without prior tuberculosis, and patients with tuberculosis and diabetes coughed more than patients without diabetes co-morbidity. Cough characteristics were similar regardless of HIV co-infection and for drug-susceptible versus drug-resistant tuberculosis. Tuberculosis treatment response may be meaningfully assessed by objectively monitoring the time spent coughing. This measure demonstrated that cough was increased in patients with TB recurrence or co-morbid diabetes, but not because of drug resistance or HIV co-infection.	en_US
dc.language.iso	eng
dc.publisher	Public Library of Science
dc.relation.ispartofseries	PLoS ONE
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Coughing	en_US
dc.subject	Tuberculosis	en_US
dc.subject	Extensively drug-resistant tuberculosis	en_US
dc.subject	Diabetes mellitus	en_US
dc.subject	Tuberculosis diagnosis and management	en_US
dc.subject	HIV	en_US
dc.subject	Drug therapy	en_US
dc.subject	HIV diagnosis and management	en_US
dc.title	Cough dynamics in adults receiving tuberculosis treatment	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1371/journal.pone.0231167
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn	1932-6203