Universidad Peruana Cayetano Heredia

The impact of insecticide treated curtains on dengue virus transmission: A cluster randomized trial in Iquitos, Peru

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dc.contributor.author Lenhart, Audrey
dc.contributor.author Morrison, Amy C.
dc.contributor.author Paz-Soldan Parlette, Valerie Andrea
dc.contributor.author Forshey, Brett M.
dc.contributor.author Cordova-Lopez, Jhonny J.
dc.contributor.author Astete, Helvio
dc.contributor.author Elder, John P.
dc.contributor.author Sihuincha, Moises
dc.contributor.author Gotlieb, Esther E.
dc.contributor.author Halsey, Eric S.
dc.contributor.author Kochel, Tadeusz J.
dc.contributor.author Scott, Thomas W.
dc.contributor.author Alexander, Neal
dc.contributor.author McCall, Philip J.
dc.date.accessioned 2020-07-14T00:02:31Z
dc.date.available 2020-07-14T00:02:31Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8326
dc.description.abstract Dengue is one of the most important vector-borne diseases, resulting in an estimated hundreds of millions of infections annually throughout the tropics. Control of dengue is heavily dependent upon control of its primary mosquito vector, Aedes aegypti. Innovative interventions that are effective at targeting the adult stage of the mosquito are needed to increase the options for effective control. The use of insecticide-treated curtains (ITCs) has previously been shown to significantly reduce the abundance of Ae. aegypti in and around homes, but the impact of ITCs on dengue virus (DENV) transmission has not been rigorously quantified. A parallel arm cluster-randomized controlled trial was conducted in Iquitos, Peru to quantify the impact of ITCs on DENV seroconversion as measured through plaque-reduction neutralization tests. Seroconversion data showed that individuals living in the clusters that received ITCs were at greater risk to seroconverting to DENV, with an average seroconversion rate of 50.6 per 100 person-years (PY) (CI: 29.9-71.9), while those in the control arm had an average seroconversion rate of 37.4 per 100 PY (CI: 15.2-51.7). ITCs lost their insecticidal efficacy within 6 months of deployment, necessitating re-treatment with insecticide. Entomological indicators did not show statistically significant differences between ITC and non-ITC clusters. It's unclear how the lack of protective efficacy reported here is attributable to simple failure of the intervention to protect against Ae. aegypti bites, or the presence of a faulty intervention during much of the follow-up period. The higher risk of dengue seroconversion that was detected in the ITC clusters may have arisen due to a false sense of security that inadvertently led to less routine protective behaviors on the part of households that received the ITCs. Our study provides important lessons learned for conducting cluster randomized trials for vector control interventions against Aedes-transmitted virus infections. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Insecticides en_US
dc.subject Entomology en_US
dc.subject Aedes aegypti en_US
dc.subject Dengue virus en_US
dc.subject Infectious disease control en_US
dc.subject Mosquitoes en_US
dc.subject Peru en_US
dc.subject Vector-borne diseases en_US
dc.title The impact of insecticide treated curtains on dengue virus transmission: A cluster randomized trial in Iquitos, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0008097
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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