Universidad Peruana Cayetano Heredia

A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis

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dc.contributor.author Martínez, Dalila Y.
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Dujardin, Jean-Claude
dc.contributor.author Polman, Katja
dc.contributor.author Adaui, Vanessa
dc.contributor.author Boelaert, Marleen
dc.contributor.author Verdonck, Kristien
dc.date.accessioned 2020-07-14T00:02:33Z
dc.date.available 2020-07-14T00:02:33Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8339
dc.description.abstract BACKGROUND: Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb(5+)) fails in 10%-30% of patients. The study objective was to assess the etiological role of intestinal helminthiasis in CL treatment failure. METHODS: An unmatched case-control study was done in 4 CL treatment sites in Peru in 2012-2015. Cases were CL patients with Sb(5+) treatment failure; controls were CL patients with Sb(5+) treatment success. Patients with a parasitologically confirmed CL diagnosis who had received supervised Sb(5+) treatment and could be classified as cases or controls were eligible. The main exposure variables were intestinal helminthiasis and strongyloidiasis, diagnosed through direct examination, rapid sedimentation, Baermann, Kato-Katz, or agar culture of stool samples. Additional exposure variables were other infections (HIV, human T-lymphotropic virus 1, tuberculosis, hepatitis B, intestinal protozoa) and noninfectious conditions (diabetes, renal insufficiency, and immunosuppressive medication). Age, gender, CL history, probable exposure place, and Leishmania species were treated as potential confounders in multiple logistic regression. RESULTS: There were 94 case and 122 control subjects. Overall, infectious and noninfectious comorbidities were frequent both among cases (64%) and controls (71%). The adjusted odds ratio (OR) for the association between any intestinal helminth infection and CL treatment failure was 0.65 (95% confidence interval [CI], 0.30-1.38), and the adjusted OR for the association between strongyloidiasis and CL treatment failure was 0.34 (95% CI, 0.11-0.92). CONCLUSIONS: In the Peruvian setting, high Sb(5+) treatment failure rates are not explained by intestinal helminthiasis. On the contrary, strongyloidiasis had a protective effect against treatment failure. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Open Forum Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject treatment failure en_US
dc.subject case–control study en_US
dc.subject cutaneous leishmaniasis en_US
dc.subject intestinal helminthiasis en_US
dc.title A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/ofid/ofaa155
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 2328-8957


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