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Toxocara Brain Infection in Pigs Is Not Associated with Visible Lesions on Brain Magnetic Resonance Imaging

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dc.contributor.author Nicoletti, Alessandra
dc.contributor.author Gomez-Puerta, Luis A.
dc.contributor.author Arroyo, Gianfranco
dc.contributor.author Bustos, Javier
dc.contributor.author Gonzalez, Armando E.
dc.contributor.author Garcia, Hector H.
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2020-07-14T00:02:36Z
dc.date.available 2020-07-14T00:02:36Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8351
dc.description.abstract Human exposure to Toxocara spp. is very frequent, and its larvae can cross the blood-brain barrier and invade the central nervous system (CNS), causing neurotoxocariasis. We aimed to establish a neurotoxocariasis animal model in pigs confirmed by necropsy. Also, the presence of larvae in the CNS was assessed using magnetic resonance imagings (MRIs), to establish brain lesions caused by the larvae migration. Ten pigs were infected intraperitoneally with 3,000 Toxocara larvae. Cerebral toxocariasis was evaluated using MRIs at days 7, 14, 21, and 49, and pigs were euthanized after the examination. Brain tissues were examined by microscopy, and five pigs presented Toxocara, most frequently at day 21 after infection. None of the 10 pigs showed alterations on MRIs. Our study confirms that intraperitoneal Toxocara infection produces neurotoxocariasis in pigs. Toxocara larvae passage through the brain does not seem to produce lesions detectable at MRIs. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:0002-9637
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Toxocara Brain Infection in Pigs Is Not Associated with Visible Lesions on Brain Magnetic Resonance Imaging en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.19-0912
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE


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