Universidad Peruana Cayetano Heredia

Diagnostic accuracy of ADA 2020 criteria for undiagnosed diabetes in a Peruvian population

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dc.contributor.author Albitres Flores, Julio Leonardo Rafael
dc.contributor.author Bernabé Ortiz, Antonio
dc.date.accessioned 2020-12-14T16:06:00Z
dc.date.available 2020-12-14T16:06:00Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8650
dc.description.abstract Aims: To assess the prevalence of undiagnosed diabetes (UDD) and the diagnostic accuracy of the American Diabetes Association (ADA) criteria to detect UDD cases in a Peruvian population. Methods: Population-based cross-sectional study. UDD was defined using fasting plasma glucose (FPG), 2-hour post-prandial plasma glucose (2 h-PPG), and glycated hemoglobin (HbA1c) traditional cut-offs. Diagnostic accuracy was estimated using areas under the receiver-operating characteristic (ROC) curve, compared with the combination of oral glucose tolerance test (FPG plus 2 h-PPG) plus HbA1c as gold standard. Results: 1609 subjects were evaluated; mean age 48.2 (SD: 10.6) years, 50.3% were women. A total of 179 (11.3%) subjects were classified as having diabetes, 41.3% of them had UDD. Area under the curve for FPG, 2 h-PPG and HbA1c was 86.5% (95% CI: 81.4–91.6%); 87.2% (95% CI: 82.2–92.2%) and 80.4% (95% CI: 74.8–86.0%), respectively. FPG sensitivity was 73.0%, whereas this value was 74.3% for 2 h-PPG and 60.8% for HbA1c. Of 74 UDD cases, 45 were positive for HbA1c, 54 for FPG and 55 for 2 h-PPG. Conclusions: 41.3% of people with diabetes do not know their diagnosis. Diagnostic accuracy of FPG and 2 h-PPG was higher than HbA1c. The most sensitive combination of two tests to detect UDD cases was FPG plus 2 h-PPG. © 2020 Elsevier B.V. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Diabetes Research and Clinical Practice
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Diabetes mellitus en_US
dc.subject Epidemiology en_US
dc.subject Sensitivity and specificity en_US
dc.subject ROC curve en_US
dc.title Diagnostic accuracy of ADA 2020 criteria for undiagnosed diabetes in a Peruvian population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.diabres.2020.108475
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1872-8227


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