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The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

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dc.contributor.author Barquera, R.
dc.contributor.author Hernández-Zaragoza, D.I.
dc.contributor.author Bravo-Acevedo, A.
dc.contributor.author Arrieta-Bolaños, E.
dc.contributor.author Clayton, S.
dc.contributor.author Acuña-Alonzo, V.
dc.contributor.author Martínez-Álvarez, J.C.
dc.contributor.author López-Gil, C.
dc.contributor.author Adalid-Sáinz, C.
dc.contributor.author Vega-Martínez, M.D.R.
dc.contributor.author Escobedo-Ruíz, A.
dc.contributor.author Juárez-Cortés, E.D.
dc.contributor.author Immel, A.
dc.contributor.author Pacheco-Ubaldo, H.
dc.contributor.author González-Medina, L.
dc.contributor.author Lona-Sánchez, A.
dc.contributor.author Lara-Riegos, J.
dc.contributor.author Sánchez-Fernández, M.G.D.J.
dc.contributor.author Díaz-López, R.
dc.contributor.author Guizar-López, G.U.
dc.contributor.author Medina-Escobedo, C.E.
dc.contributor.author Arrazola-García, M.A.
dc.contributor.author Montiel-Hernández, G.D.
dc.contributor.author Hernández-Hernández, O.
dc.contributor.author Ramos-de la Cruz, F.D.R.
dc.contributor.author Juárez-Nicolás, F.
dc.contributor.author Pantoja-Torres, J.A.
dc.contributor.author Rodríguez-Munguía, T.J.
dc.contributor.author Juárez-Barreto, V.
dc.contributor.author Delgado-Aguirre, H.
dc.contributor.author Escutia-González, A.B.
dc.contributor.author Goné-Vázquez, I.
dc.contributor.author Benítez-Arvizu, G.
dc.contributor.author Arellano-Prado, F.P.
dc.contributor.author García-Arias, V.E.
dc.contributor.author Rodríguez-López, M.E.
dc.contributor.author Méndez-Mani, P.
dc.contributor.author García-Álvarez, R.
dc.contributor.author González-Martínez, M.D.R.
dc.contributor.author Aquino-Rubio, G.
dc.contributor.author Escareño-Montiel, N.
dc.contributor.author Vázquez-Castillo, T.V.
dc.contributor.author Uribe-Duarte, M.G.
dc.contributor.author Ruíz-Corral, M.D.J.
dc.contributor.author Ortega-Yáñez, A.
dc.contributor.author Bernal-Felipe, N.
dc.contributor.author Gómez-Navarro, B.
dc.contributor.author Arriaga-Perea, A.J.
dc.contributor.author Martínez-Bezies, V.
dc.contributor.author Macías-Medrano, R.M.
dc.contributor.author Aguilar-Campos, J.A.
dc.contributor.author Solís-Martínez, R.
dc.contributor.author Serrano-Osuna, R.
dc.contributor.author Sandoval-Sandoval, M.J.
dc.contributor.author Jaramillo-Rodríguez, Y.
dc.contributor.author Salgado-Adame, A.
dc.contributor.author Juárez-de la Cruz, F.
dc.contributor.author Novelo-Garza, B.
dc.contributor.author Pavón-Vargas, M.D.L.Á.
dc.contributor.author Salgado-Galicia, N.
dc.contributor.author Bortolini, M.C.
dc.contributor.author Gallo, C.
dc.contributor.author Bedoya, G.
dc.contributor.author Rothhammer, F.
dc.contributor.author González-José, R.
dc.contributor.author Ruiz-Linares, A.
dc.contributor.author Canizales-Quinteros, S.
dc.contributor.author Romero-Hidalgo, S.
dc.contributor.author Krause, J.
dc.contributor.author Zúñiga, J.
dc.contributor.author Yunis, E.J.
dc.contributor.author Bekker-Méndez, C.
dc.contributor.author Granados, J.
dc.date.accessioned 2020-12-14T16:06:06Z
dc.date.available 2020-12-14T16:06:06Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8662
dc.description.abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1879-1166
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.humimm.2020.06.008
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03


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