Universidad Peruana Cayetano Heredia

Prevalence of diabetes and hypertension and their associated risks for poor outcomes in Covid-19 Patients

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dc.contributor.author Barrera, F.J.
dc.contributor.author Shekhar, S.
dc.contributor.author Wurth, R.
dc.contributor.author Moreno-Pena, P.J.
dc.contributor.author Ponce, O.J.
dc.contributor.author Hajdenberg, M.
dc.contributor.author Alvarez-Villalobos, N.A.
dc.contributor.author Hall, J.E.
dc.contributor.author Schiffrin, E.L.
dc.contributor.author Eisenhofer, G.
dc.contributor.author Porter, F.
dc.contributor.author Brito, J.P.
dc.contributor.author Bornstein, S.R.
dc.contributor.author Stratakis, C.A.
dc.contributor.author González-González, J.G.
dc.contributor.author Rodíguez-Gutiérrez, R.
dc.contributor.author Hannah-Shmouni, F.
dc.date.accessioned 2020-12-14T16:06:06Z
dc.date.available 2020-12-14T16:06:06Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8663
dc.description.abstract Coronavirus disease 2019 (Covid-19) has affected millions of people and may disproportionately affect those with hypertension and diabetes. Because of inadequate methods in published systematic reviews, the prevalence of diabetes and hypertension and associated risks of poor outcomes in Covid-19 patients are unknown. We searched databases from December 1, 2019, to April 6, 2020, and selected observational peer-reviewed studies in English of patients with Covid-19. Independent reviewers extracted data on study participants, interventions, and outcomes and assessed risk of bias, and the certainty of evidence. We included 65 (15 794 participants) observational studies at moderate to high risk of bias. Overall prevalence of diabetes and hypertension was 12% (95% confidence interval [CI], 10-15; n = 12 870; I2: 89%), and 17% (95% CI, 13-22; n = 12 709; I2: 95%), respectively. In severe Covid-19, the prevalence of diabetes and hypertension were 18% (95% CI, 16-20; n = 1099; I2: 0%) and 32% (95% CI, 16-54; n = 1078; I2: 63%), respectively. Unadjusted relative risk for intensive care unit admission and mortality were 1.96 (95% CI, 1.19-3.22; n = 8890; I2: 80%; P = .008) and 2.78 (95% CI, 1.39-5.58; n = 2058; I2: 75%; P = .0004) for diabetics; and 2.95 (95% CI, 2.18-3.99; n = 1737; I2: 0%; P < .001) and 2.39 (95% CI, 1.54-3.73; n = 3107; I2: 66%; P < .001) for hypertensives. Neither diabetes (1.50; 95% CI, 0.90-2.50; n = 1991; I2: 74%; P = .119) nor hypertension (1.48; 95% CI, 0.99-2.23; n = 2023; I2: 69%; P = .058) was associated with severe Covid-19. In conclusion, the risk of intensive care unit admission and mortality for patients with diabetes or hypertension who developed Covid-19 is increased compared with those without these comorbidities. en_US
dc.language.iso eng
dc.publisher Endocrine Society
dc.relation.ispartofseries Journal of the Endocrine Society
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Covid-19 en_US
dc.subject SARS-CoV-2 en_US
dc.subject diabetes mellitus en_US
dc.subject hypertension en_US
dc.subject endocrinology en_US
dc.title Prevalence of diabetes and hypertension and their associated risks for poor outcomes in Covid-19 Patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1210/jendso/bvaa102
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 2472-1972


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