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Abortive vampire bat rabies infections in peruvian peridomestic livestock

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dc.contributor.author Benavides, J.A.
dc.contributor.author Velasco-Villa, A.
dc.contributor.author Godino, L.C.
dc.contributor.author Satheshkumar, P.S.
dc.contributor.author Ruby, N.
dc.contributor.author Rojas-Paniagua, E.
dc.contributor.author Shiva Ramayoni, Carlos Martin
dc.contributor.author Falcon Perez, Nestor Gerardo
dc.contributor.author Streicker, D.G.
dc.date.accessioned 2020-12-14T16:06:07Z
dc.date.available 2020-12-14T16:06:07Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8665
dc.description.abstract Rabies virus infections normally cause universally lethal encephalitis across mammals. However, ‘abortive infections’ which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. We detected rabies virus neutralizing antibody titers in 11, 5 and 3.6% of cows, goats and sheep respectively and seropositive animals did not die from rabies within two years after sampling. Seroprevalence was correlated with the number of local livestock rabies mortalities reported one year prior but also one year after sample collection. This suggests that serological status of livestock can indicate the past and future levels of rabies risk to non-reservoir hosts. To our knowledge, this is the first report of anti-rabies antibodies among goats and sheep, suggesting widespread abortive infections among livestock in vampire bat rabies endemic areas. Future research should resolve the within-host biology underlying clearance of rabies infections. Cost-effectiveness analyses are also needed to evaluate whether serological monitoring of livestock can be a viable complement to current monitoring of vampire bat rabies risk based on animal mortalities alone. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Livestock en_US
dc.subject Bats en_US
dc.subject Rabies virus en_US
dc.subject Rabies en_US
dc.subject Serology en_US
dc.subject Medical risk factors en_US
dc.subject Vaccination and immunization en_US
dc.subject Sheep en_US
dc.title Abortive vampire bat rabies infections in peruvian peridomestic livestock en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0008194
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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