Abortive vampire bat rabies infections in peruvian peridomestic livestock

Falcon Perez, Nestor Gerardo; Godino, L.C.; Rojas-Paniagua, E.; Satheshkumar, P.S.; Streicker, D.G.; Benavides, J.A.; Ruby, N.; Velasco-Villa, A.; Shiva Ramayoni, Carlos Martin

dc.contributor.author	Benavides, J.A.
dc.contributor.author	Velasco-Villa, A.
dc.contributor.author	Godino, L.C.
dc.contributor.author	Satheshkumar, P.S.
dc.contributor.author	Ruby, N.
dc.contributor.author	Rojas-Paniagua, E.
dc.contributor.author	Shiva Ramayoni, Carlos Martin
dc.contributor.author	Falcon Perez, Nestor Gerardo
dc.contributor.author	Streicker, D.G.
dc.date.accessioned	2020-12-14T16:06:07Z
dc.date.available	2020-12-14T16:06:07Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8665
dc.description.abstract	Rabies virus infections normally cause universally lethal encephalitis across mammals. However, ‘abortive infections’ which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. We detected rabies virus neutralizing antibody titers in 11, 5 and 3.6% of cows, goats and sheep respectively and seropositive animals did not die from rabies within two years after sampling. Seroprevalence was correlated with the number of local livestock rabies mortalities reported one year prior but also one year after sample collection. This suggests that serological status of livestock can indicate the past and future levels of rabies risk to non-reservoir hosts. To our knowledge, this is the first report of anti-rabies antibodies among goats and sheep, suggesting widespread abortive infections among livestock in vampire bat rabies endemic areas. Future research should resolve the within-host biology underlying clearance of rabies infections. Cost-effectiveness analyses are also needed to evaluate whether serological monitoring of livestock can be a viable complement to current monitoring of vampire bat rabies risk based on animal mortalities alone.	en_US
dc.language.iso	eng
dc.publisher	Public Library of Science
dc.relation.ispartofseries	PLoS Neglected Tropical Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Livestock	en_US
dc.subject	Bats	en_US
dc.subject	Rabies virus	en_US
dc.subject	Rabies	en_US
dc.subject	Serology	en_US
dc.subject	Medical risk factors	en_US
dc.subject	Vaccination and immunization	en_US
dc.subject	Sheep	en_US
dc.title	Abortive vampire bat rabies infections in peruvian peridomestic livestock	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1371/journal.pntd.0008194
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1935-2735