Universidad Peruana Cayetano Heredia

Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys

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dc.contributor.author Carrera, J.-P.
dc.contributor.author Cucunubá, Z.M.
dc.contributor.author Neira, K.
dc.contributor.author Lambert, B.
dc.contributor.author Pittí, Y.
dc.contributor.author Liscano, J.
dc.contributor.author Garzón, J.L.
dc.contributor.author Beltran, D.
dc.contributor.author Collado-Mariscal, L.
dc.contributor.author Saenz, L.
dc.contributor.author Sosa, N.
dc.contributor.author Rodriguez-Guzman, L.D.
dc.contributor.author González, P.
dc.contributor.author Lezcano, A.G.
dc.contributor.author Pereyra-Elías, R.
dc.contributor.author Valderrama, A.
dc.contributor.author Weaver, S.C.
dc.contributor.author Vittor, A.Y.
dc.contributor.author Armién, B.
dc.contributor.author Pascale, J.-M.
dc.contributor.author Donnelly, C.A.
dc.date.accessioned 2020-12-14T16:06:13Z
dc.date.available 2020-12-14T16:06:13Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8680
dc.description.abstract Madariaga virus (MADV) has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June 2017, a fatal MADV infection was confirmed in a community of Darien Province. We conducted a cross-sectional outbreak investigation with human and mosquito collections in July 2017, where sera were tested for alphavirus antibodies and viral RNA. In addition, by applying a catalytic, force-of-infection (FOI) statistical model to two serosurveys from Darien Province in 2012 and 2017, we investigated whether endemic or epidemic alphavirus transmission occurred historically. In 2017, MADV and VEEV IgM seroprevalences were 1.6% and 4.4%, respectively; IgG antibody prevalences were MADV: 13.2%, VEEV: 16.8%, Una virus (UNAV): 16.0%, and Mayaro virus: 1.1%. Active viral circulation was not detected. Evidence of MADV and UNAV infection was found near households, raising questions about its vectors and enzootic transmission cycles. Insomnia was associated with MADV and VEEV infections, depression symptoms were associated with MADV, and dizziness with VEEV and UNAV. Force-of-infection analyses suggest endemic alphavirus transmission historically, with recent increased human exposure to MADV and VEEV in Aruza and Mercadeo, respectively. The lack of additional neurological cases suggests that severe MADV and VEEV infections occur only rarely. Our results indicate that over the past five decades, alphavirus infections have occurred at low levels in eastern Panama, but that MADV and VEEV infections have recently increased-potentially during the past decade. Endemic infections and outbreaks of MADV and VEEV appear to differ spatially in some locations of eastern Panama. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Endemic Human Alphavirus en_US
dc.subject Epidemic Human Alphavirus en_US
dc.subject Panama en_US
dc.subject Cross-Sectional Survey en_US
dc.title Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.20-0408
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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