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Household clustering of SARS-CoV-2 in community settings: A study from rural ecuador

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dc.contributor.author Del Brutto, O.H.
dc.contributor.author Costa, A.F.
dc.contributor.author Mera, R.M.
dc.contributor.author Recalde, B.Y.
dc.contributor.author Bustos, J.A.
dc.contributor.author García, H.H.
dc.date.accessioned 2020-12-14T16:06:19Z
dc.date.available 2020-12-14T16:06:19Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8697
dc.description.abstract The SARS-CoV-2 pandemic is now expanding into the developing world with devastating consequences. Departing from a population-based study in rural Ecuador where all adult individuals (aged 40 years or older) were tested for SARS-CoV-2 IgG and IgM antibodies, we expanded it to include a house-based case–control component assessing in-house clustering and other variables potentially associated with infection. We selected houses where exactly two study participants lived and were both seropositive (case-houses), and matched 1:1 to control-houses where both were seronegative. Younger household members had an antibody test performed. Infected household members were found in 33 (92%) case-houses and in only six (17%) control-houses. In 28/29 discordant house pairs, the case-house had seropositive household members and the control-house did not (odds ratio: 28; 95% CI: 4.6–1,144). Our data demonstrate strong in-house clustering of infection in community settings, stressing the importance of early case ascertainment and isolation for SARS-CoV-2 control. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:1476-1645
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Household clustering of SARS-CoV-2 in community settings: A study from rural ecuador en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.20-0688
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06


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