Household clustering of SARS-CoV-2 in community settings: A study from rural ecuador

Del Brutto, O.H.; García Lescano, Héctor Hugo; Mera, R.M.; Bustos Palomino, Javier Arturo; Recalde, B.Y.; Costa, A.F.

dc.contributor.author	Del Brutto, O.H.
dc.contributor.author	Costa, A.F.
dc.contributor.author	Mera, R.M.
dc.contributor.author	Recalde, B.Y.
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2020-12-14T16:06:19Z
dc.date.available	2020-12-14T16:06:19Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8697
dc.description.abstract	The SARS-CoV-2 pandemic is now expanding into the developing world with devastating consequences. Departing from a population-based study in rural Ecuador where all adult individuals (aged 40 years or older) were tested for SARS-CoV-2 IgG and IgM antibodies, we expanded it to include a house-based case–control component assessing in-house clustering and other variables potentially associated with infection. We selected houses where exactly two study participants lived and were both seropositive (case-houses), and matched 1:1 to control-houses where both were seronegative. Younger household members had an antibody test performed. Infected household members were found in 33 (92%) case-houses and in only six (17%) control-houses. In 28/29 discordant house pairs, the case-house had seropositive household members and the control-house did not (odds ratio: 28; 95% CI: 4.6–1,144). Our data demonstrate strong in-house clustering of infection in community settings, stressing the importance of early case ascertainment and isolation for SARS-CoV-2 control.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	SARS-CoV-2	en_US
dc.subject	Community Settings	en_US
dc.subject	Rural	en_US
dc.subject	Ecuador	en_US
dc.title	Household clustering of SARS-CoV-2 in community settings: A study from rural ecuador	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.20-0688
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645