SARS-CoV-2-related mortality in a rural Latin American population

Del Brutto, O.H.; García Lescano, Héctor Hugo; Mera, R.M.; Bustos Palomino, Javier Arturo; Recalde, B.Y.; Costa, A.F.

dc.contributor.author	Del Brutto, O.H.
dc.contributor.author	Costa, A.F.
dc.contributor.author	Mera, R.M.
dc.contributor.author	Recalde, B.Y.
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2020-12-14T16:06:20Z
dc.date.available	2020-12-14T16:06:20Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8698
dc.description.abstract	A sudden increase in adult mortality associated with respiratory diseases was noticed in Atahualpa (a rural Ecuadorian village), coinciding with the introduction of SARS-CoV-2 in the region. From a total of 1,852 individuals aged ≥18 years, 40 deaths occurred between January and June, 2020. In addition, a seroprevalence survey showed that 45% of the adult population have SARS-CoV-2 antibodies. Verbal autopsies revealed SARS-CoV-2 as the most likely cause of death in 29 cases. The mean age of suspected or confirmed SARS-CoV-2 cases was 76.9 ± 12.1 years, while that of those dying from unrelated causes was 60.3 ± 20.4 years (p = 0.003). The overall mortality rate was 21.6 per 1,000 population (95% C.I.: 15.9 – 29.2), almost three-quarters of it due to SARS-CoV-2 (15.7 per 1,000; 95% C.I.: 11 – 22.4). This configures a 266% of excess mortality when compared to 5.9 per 1,000 (95% C.I.: 3.3 – 10.6) deaths from other causes. When SARS-CoV-2 mortality rate was calculated in individuals aged ≥60 years, it raised up to 68.9 per 1,000 (95% C.I.: 47.8 – 98.4). After peaking in April and May, mortality significantly decreased. It is possible that the high proportion of infected individuals and the resulting herd immunity contributed to the observed reduction in mortality.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	International Journal of Infectious Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	SARS-CoV-2	en_US
dc.subject	mortality	en_US
dc.subject	rural	en_US
dc.subject	Latin American	en_US
dc.title	SARS-CoV-2-related mortality in a rural Latin American population	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.ijid.2020.08.003
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn	1878-3511