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Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort

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dc.contributor.author Elera-Fitzcarrald, C.
dc.contributor.author Reátegui-Sokolova, C.
dc.contributor.author Gamboa-Cárdenas, R.V.
dc.contributor.author Medina, M.
dc.contributor.author Zevallos, F.
dc.contributor.author Pimentel Quiroz, Víctor Roman
dc.contributor.author Zeña-Huancas, P.A.
dc.contributor.author Pastor-Asurza, C.A.
dc.contributor.author Perich-Campos, R.A.
dc.contributor.author Rodríguez-Bellido, Z.J.
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Ugarte Gil, Manuel Francisco
dc.date.accessioned 2020-12-14T16:06:20Z
dc.date.available 2020-12-14T16:06:20Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8701
dc.description.abstract Objective: To define the factors associated with fatigue in Mestizo patients with Systemic Lupus Erythematosus (SLE). Methods: This is a cross-sectional study of SLE patients from a single center cohort. Visits were performed every six months. For these analyses, the first visit between October 2017 and December 2018 was included. Demographic and clinical characteristics as well as treatment were recorded at every visit. Fatigue was ascertained with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-FT), Health-Related Quality of Life (HRQoL) with the LupusQoL, disease activity with the Systemic Lupus Erythematosus Disease Activity Index –2 K (SLEDAI-2K), and damage with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology damage index (SDI). Prednisone use was recorded as current daily dose. Immunosuppressive drugs and antimalarial use were recorded as current, past or never. Univariable and multivariable analyses were performed using linear regression models. For the multivariable analyses, model selection followed a backward elimination procedure. Results: Two hundred and twenty-six patients were evaluated. The mean (SD) age at diagnosis was 35.6 (13.1) years, 211 (93.4%) were female; and disease duration was 11.0 (7.3) years. The mean SLEDAI and SDI were 2.4 (3.5) and 1.3 (1.5), respectively. The mean FACIT-FT was 33.1 (10.8). On the multivariable analysis, age at diagnosis and some domains of HRQoL (physical health, emotional health and fatigue) remained associated. Conclusions: Age at diagnosis is negatively associated with fatigue whereas HRQoL domains like physical health, emotional health and fatigue are positively associated with fatigue. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject quality of life en_US
dc.subject fatigue en_US
dc.subject systemic lupus erythematosus en_US
dc.subject patients en_US
dc.title Age at diagnosis and health-related quality of life are associated with fatigue in systemic lupus erythematosus patients: Data from the Almenara Lupus Cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/0961203320947472
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1477-0962


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