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Impact of fractures and orthopedic surgeries in patients with htlv-1 associated myelopathy/tropical spastic paraparesis

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dc.contributor.author Julca-Copello, P.
dc.contributor.author Schwalb, A.
dc.contributor.author Cachay, R.
dc.contributor.author Tipismana, M.
dc.contributor.author Alvarez, C.
dc.contributor.author Mejía, F.
dc.contributor.author González-Lagos, E.
dc.contributor.author Gotuzzo, E.
dc.date.accessioned 2020-12-14T16:06:26Z
dc.date.available 2020-12-14T16:06:26Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8722
dc.description.abstract Introduction: In patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) gait disturbance is a predominant feature that leads to falls and fractures, which can further aggravate disability. We sought to evaluate the impact of fractures and orthopedic surgeries in patients with HAM/TSP. Methods: We retrieved the medical records of HAM/TSP patients enrolled in our study center’s HTLV-1 clinical cohort between 1989-2018. The selection criteria included: (1) diagnosis of HTLV-1 infection using two enzyme-linked immunosorbent assays and/or a confirmatory test, (2) clinical diagnosis of HAM/TSP by neurological assessment, and (3) fractures associated with HAM/TSP. Results: We identified 24 cases of fractures, 70% of which were females. The median age at the time of fracture was 60 years (IQR=24). Six cases reported fractures in patients under 45 years old. Ten patients (42%) had hip/coccyx fractures, seven (29%) were in the lower extremities, and four (17%) in the upper extremities. Half of these patients reported the use of wheelchairs. Five patients who had previously used canes required the use of wheelchairs after the reported fracture. Eight patients underwent corrective orthopedic surgery as a result of the fracture. Conclusions: For HAM/TSP patients, fractures are a complication that can exacerbate their severe impairment. en_US
dc.language.iso eng
dc.publisher SciELO
dc.relation.ispartof urn:issn:1678-9849
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Impact of fractures and orthopedic surgeries in patients with htlv-1 associated myelopathy/tropical spastic paraparesis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1590/0037-8682-0101-2020
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06


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