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Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants.

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dc.contributor.author Labayo, H.K.M.
dc.contributor.author Pajuelo Travezaño, Monica Jhenny
dc.contributor.author Tohma, K.
dc.contributor.author Ford-Siltz, L.A.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Cabrera, L.
dc.contributor.author Mayta, Holger
dc.contributor.author Sanchez, Gerardo
dc.contributor.author Toledo Cornejo, Anniuska
dc.contributor.author Bern, C.
dc.contributor.author Dapat, C.
dc.contributor.author Nochi, T.
dc.contributor.author Parra, G.I.
dc.contributor.author Oshitani, H.
dc.contributor.author Saito, M.
dc.date.accessioned 2020-12-14T16:06:28Z
dc.date.available 2020-12-14T16:06:28Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8724
dc.description.abstract Background: Norovirus (NV) causes acute gastroenteritis in infants. Humoral and fecal immunoglobulin A (IgA) responses have been correlated with protection against NV; however, the role of breast milk IgA against NV infection and associated diarrhea is still unknown. This study aimed to evaluate the protective role of NV-specific IgA (NV-IgA) in breast milk. Methods: Ninety-five breast milk samples collected from mothers enrolled in a 2016–2017 Peruvian birth cohort study were tested for total IgA and NV-IgA by ELISA using GII·4 variants and non-GII·4 genotype virus-like particles (VLPs). Breast milk samples were grouped according to the NV infection and diarrheal status of infants: NV positive with diarrhea (NV+D+, n=18); NV positive without diarrhea (NV+D-, n=37); and NV negative without diarrhea (NV-D-, n=40). The percent positivity and titer of NV-IgA were compared among groups. The cross-reactivity was estimated based on the correlation of ratio between NV-IgA against GII·4 variants and non-GII·4 genotype VLPs. Findings: NV-IgA had high positivity rates against different VLPs, especially against GII (89–100%). The NV+D- group had higher percent positivity (89% vs. 61%, p=0·03) and median titer (1:100 vs 1:50, p=0·03) of NV-IgA than the NV+D+ group against GI·1 VLPs. A relatively high correlation between different GII·4 variants (0·87) and low correlation between genogroups (0·23–0·37) were observed. Interpretation: Mothers with high positivity rates and titers of NV-IgA in breast milk had NV infected infants with reduced diarrheal symptoms. Antigenic relatedness to the genetic diversity of human norovirus was suggested. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries eClinicalMedicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Norovirus en_US
dc.subject Breast milk en_US
dc.subject Immunoglobulin A en_US
dc.subject Diarrhea en_US
dc.subject Maternal immunity en_US
dc.title Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.eclinm.2020.100561
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 2589-5370


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