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HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

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dc.contributor.author Loiseau, C.
dc.contributor.author Brites, D.
dc.contributor.author Reinhard, M.
dc.contributor.author Zürcher, K.
dc.contributor.author Borrell, S.
dc.contributor.author Ballif, M.
dc.contributor.author Fenner, L.
dc.contributor.author Cox, H.
dc.contributor.author Rutaihwa, L.K.
dc.contributor.author Wilkinson, R.J.
dc.contributor.author Yotebieng, M.
dc.contributor.author Jane Carter, E.
dc.contributor.author Abimiku, A.
dc.contributor.author Marcy, O.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Avihingsanon, A.
dc.contributor.author Zetola, N.
dc.contributor.author Doulla, B.
dc.contributor.author Böttger, E.C.
dc.contributor.author Egger, M.
dc.contributor.author Gagneux, S.
dc.date.accessioned 2020-12-14T16:06:29Z
dc.date.available 2020-12-14T16:06:29Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8729
dc.description.abstract We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Antimicrobial Agents and Chemotherapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HIV-TB coinfection en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Drug resistance en_US
dc.subject Fitness cost en_US
dc.subject Rifampicin en_US
dc.title HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.00782-20
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1098-6596


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