Universidad Peruana Cayetano Heredia
HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis
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| dc.contributor.author | Loiseau, C. | |
| dc.contributor.author | Brites, D. | |
| dc.contributor.author | Reinhard, M. | |
| dc.contributor.author | Zürcher, K. | |
| dc.contributor.author | Borrell, S. | |
| dc.contributor.author | Ballif, M. | |
| dc.contributor.author | Fenner, L. | |
| dc.contributor.author | Cox, H. | |
| dc.contributor.author | Rutaihwa, L.K. | |
| dc.contributor.author | Wilkinson, R.J. | |
| dc.contributor.author | Yotebieng, M. | |
| dc.contributor.author | Jane Carter, E. | |
| dc.contributor.author | Abimiku, A. | |
| dc.contributor.author | Marcy, O. | |
| dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
| dc.contributor.author | Avihingsanon, A. | |
| dc.contributor.author | Zetola, N. | |
| dc.contributor.author | Doulla, B. | |
| dc.contributor.author | Böttger, E.C. | |
| dc.contributor.author | Egger, M. | |
| dc.contributor.author | Gagneux, S. | |
| dc.date.accessioned | 2020-12-14T16:06:29Z | |
| dc.date.available | 2020-12-14T16:06:29Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8729 | |
| dc.description.abstract | We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. | en_US |
| dc.language.iso | eng | |
| dc.publisher | American Society for Microbiology | |
| dc.relation.ispartofseries | Antimicrobial Agents and Chemotherapy | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | HIV-TB coinfection | en_US |
| dc.subject | Mycobacterium tuberculosis | en_US |
| dc.subject | Drug resistance | en_US |
| dc.subject | Fitness cost | en_US |
| dc.subject | Rifampicin | en_US |
| dc.title | HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1128/AAC.00782-20 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.05 | |
| dc.relation.issn | 1098-6596 |
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