Population Screening for Urine Antigens to Detect Asymptomatic Subarachnoid Neurocysticercosis: A Pilot Study in Northern Peru

McCleery, E.; García Lescano, Héctor Hugo; Allen, S.E.; Dorny, P.; Moyano, L.M.; Castillo Berrios, Yesenia; Muro Ecca, Claudio Alberto; Vilchez Barreto, Percy Mcquen; Gamboa Morán, Ricardo; O’Neal, S.E.

dc.contributor.author	McCleery, E.
dc.contributor.author	Allen, S.E.
dc.contributor.author	Moyano, L.M.
dc.contributor.author	Gamboa Morán, Ricardo
dc.contributor.author	Vilchez Barreto, Percy Mcquen
dc.contributor.author	Muro Ecca, Claudio Alberto
dc.contributor.author	Castillo Berrios, Yesenia
dc.contributor.author	Dorny, P.
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	O’Neal, S.E.
dc.date.accessioned	2020-12-14T16:06:33Z
dc.date.available	2020-12-14T16:06:33Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8737
dc.description.abstract	Subarachnoid neurocysticercosis (SANCC) is a severe and progressive brain infection with Taenia solium. We performed a pilot study of noninvasive screening for SANCC in two endemic villages in northern Peru using a urine antigen screen followed by brain magnetic resonance imaging for participants with elevated levels of antigen. Among the 978 participants screened, we identified eight individuals with SANCC, many of whom were asymptomatic. This represents a minimum prevalence of 0.8% of SANCC, a level higher than expected based on prior studies, and a positive predictive value of 62% for our novel urine screening test. Future studies should confirm whether early detection and management improve clinical outcomes.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Urine Antigens	en_US
dc.subject	Asymptomatic Subarachnoid Neurocysticercosis	en_US
dc.subject	Northern Peru	en_US
dc.title	Population Screening for Urine Antigens to Detect Asymptomatic Subarachnoid Neurocysticercosis: A Pilot Study in Northern Peru	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.20-0196
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645