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Clinical profile of human T-lymphotropic virus type I: A forgotten infection in pediatrics

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dc.contributor.author Mejía-Mertel, J.
dc.contributor.author Gómez-Banoy, N.
dc.contributor.author Rojas-Hernández, J.P.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2020-12-14T16:06:33Z
dc.date.available 2020-12-14T16:06:33Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8738
dc.description.abstract The Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus with oncogenic properties, affects around ten to twenty million people worldwide. The most common disorders associated with HTLV-1 infection are T-cell leukemia/lymphoma (ALT) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Studies have reported other clinical manifestations in HTLV-1 seropositive patients, including inflammatory disorders, co-infections with opportunistic agents, and pulmonary diseases. Objective: Here, we aim to describe a cohort of juvenile patients with confirmed HTLV-1 infection that showed clinical manifestations other than neurological symptoms. Methodology and patients: Retrospective analysis of clinical data describing background and clinical findings of 12 juvenile patients with confirmed HTLV-1 infection, attended during January 2018 to February 2020 in a pediatric referral hospital in Cali, Colombia. Results: 11 out 12 patients were from Colombiás Pacific coast, 10 suffered from significant nutritional deficiencies. Six exhibited dermatological findings, 3 compatible with infective dermatitis. None of the cases exhibited clinical or laboratory findings suggesting ALT or HAM/TPS. Eight patients had structural lung disease assessed by chest Computed Tomography (CT) scans; 4 of them tested positive for galactomannan antigen in bronchoalveolar fluid suggesting pulmonary aspergillosis, and 2 others exhibited a positive PCR testing for tuberculosis. Three patients were diagnosed with autoimmune disorders; 1 patient with Crohńs Diseases, 1 case of autoimmune thrombocytopenic purpura, and a patient with Vogt-Koyanagi-Harada syndrome (non-granulomatous uveitis). Conclusions: There is a broad range of clinical manifestations in pediatric HTLV-1 patients, and the clinician should consider structural pulmonary disease, opportunistic co-infections and autoimmune disorders in the diagnostic algorithm. en_US
dc.language.iso eng
dc.publisher Asociación Colombiana de Infectología
dc.relation.ispartofseries Infectio
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject Retroviridae en_US
dc.subject Child en_US
dc.subject HTLV-1 Infections en_US
dc.title Clinical profile of human T-lymphotropic virus type I: A forgotten infection in pediatrics en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.22354/in.v25i1.905
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 2422-3794


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