Universidad Peruana Cayetano Heredia

Antimicrobial activity and antiadherent effect of peruvian psidium guajava (Guava) leaves on a cariogenic biofilm model

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dc.contributor.author Millones-Gómez, P.A.
dc.contributor.author Maurtua Torres, Dora Jesus
dc.contributor.author Bacilio-Amaranto, R.
dc.contributor.author Calla-Poma, R.D.
dc.contributor.author Requena-Mendizabal, M.F.
dc.contributor.author Valderrama-Negron, A.C.
dc.contributor.author Calderon-Miranda, M.A.
dc.contributor.author Calla-Poma, R.A.
dc.contributor.author Huauya Leuyacc, M.E.
dc.date.accessioned 2020-12-14T16:06:33Z
dc.date.available 2020-12-14T16:06:33Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8740
dc.description.abstract Aim: Phytomedicine has been commonly practiced as a form of traditional medicine in various cultures for the treatment of oral diseases. Recently, it has gained importance as an alternative to conventional treatment. Several extracts of plants and fruits have been recently evaluated for their potential activity against microorganisms involved in the development of dental caries. The purpose of this study was to evaluate the antimicrobial activity and antiadherent effect of the crude organic extract (COE) and three partitions (aqueous, butanolic, and chloroformic) of Psidium guajava (guava) leaves on a cariogenic biofilm model. Materials and methods: Guava leaves were obtained from the mountains of northern Peru, where they grow wild and free of pesticides. The antimicrobial activity of the COEs and partitions against Streptococcus mutans and Streptococcus gordonii was determined by measuring the inhibition halos, while the effect on biofilm adhesion was determined by measuring the optical density using spectrophotometry. Results: An antibacterial effect of the COE and chloroformic partition against S. gordonii (p < 0.05) was found, as was a significant effect on biofilm adherence, with a minimum inhibitory concentration (MIC) of 0.78 mg/mL, which was maintained throughout the 7 days of evaluation. Conclusion: We conclude that the COEs and their chloroformic partition have antimicrobial and antibiotic effects against this strain of S. gordonii, making them of particular interest for evaluation as a promising alternative for the prevention of dental caries. Clinical significance: By knowing the antimicrobial effect of Psidium guajava, this substance can be effectively used in products aimed to prevent dental caries and periodontal disease. © The Author(s). en_US
dc.language.iso eng
dc.publisher Jaypee Brothers Medical Publishers
dc.relation.ispartofseries Journal of Contemporary Dental Practice
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cariogenic biofilm en_US
dc.subject Dental caries en_US
dc.subject Psidium guajava en_US
dc.subject Streptococcus gordonii en_US
dc.subject Streptococcus mutans en_US
dc.title Antimicrobial activity and antiadherent effect of peruvian psidium guajava (Guava) leaves on a cariogenic biofilm model en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5005/JP-JOURNALS-10024-2893
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1526-3711


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