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Iron metabolism in high-altitude residents

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dc.contributor.author Muckenthaler, M.U.
dc.contributor.author Mairbäurl, H.
dc.contributor.author Gassmann, M.
dc.date.accessioned 2020-12-14T16:10:01Z
dc.date.available 2020-12-14T16:10:01Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8744
dc.description.abstract Residents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data on how iron metabolism adapts when living in a hypoxic environment. Our analysis reveals that long-term adaptation to high altitude enables healthy individuals to maintain their iron stores within the physiological range despite elevated requirements for erythropoiesis. However, in vulnerable populations with increased iron demand (e.g., pregnant women or exercising individuals), iron stores are less likely to be replenished quickly when living at high altitude. Future studies need to address whether different ethnicities have acquired genetic mechanisms to adapt to the elevated iron demand for erythropoiesis at high altitude. © 2020 the American Physiological Society en_US
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartof urn:issn:1522-1601
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Iron metabolism in high-altitude residents en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1152/japplphysiol.00019.2020
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08

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