Iron metabolism in high-altitude residents

Mairbäurl, H.; Gassmann, M.; Muckenthaler, M.U.

dc.contributor.author	Muckenthaler, M.U.
dc.contributor.author	Mairbäurl, H.
dc.contributor.author	Gassmann, M.
dc.date.accessioned	2020-12-14T16:10:01Z
dc.date.available	2020-12-14T16:10:01Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8744
dc.description.abstract	Residents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data on how iron metabolism adapts when living in a hypoxic environment. Our analysis reveals that long-term adaptation to high altitude enables healthy individuals to maintain their iron stores within the physiological range despite elevated requirements for erythropoiesis. However, in vulnerable populations with increased iron demand (e.g., pregnant women or exercising individuals), iron stores are less likely to be replenished quickly when living at high altitude. Future studies need to address whether different ethnicities have acquired genetic mechanisms to adapt to the elevated iron demand for erythropoiesis at high altitude.	en_US
dc.language.iso	eng
dc.publisher	American Physiological Society
dc.relation.ispartofseries	Journal of Applied Physiology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Chronic Adaptation	en_US
dc.subject	High altitude	en_US
dc.subject	Iron	en_US
dc.title	Iron metabolism in high-altitude residents	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1152/japplphysiol.00019.2020
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn	1522-1601