Universidad Peruana Cayetano Heredia

Is mother's own milk lactoferrin intake associated with reduced neonatal sepsis, necrotizing enterocolitis, and death?

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dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Mendoza, K.
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Zegarra, J.
dc.contributor.author Bellomo, S.
dc.contributor.author Jacobs, J.
dc.contributor.author Cossey, V.
dc.date.accessioned 2020-12-14T16:10:01Z
dc.date.available 2020-12-14T16:10:01Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8750
dc.description.abstract Introduction: Lactoferrin (LF) is a protective protein present in milk with anti-infective and immune-modulating properties. Objectives: The aim of this study was to determine the association of maternal LF intake and mother's own milk intake in the first 10 days of life on the prevention of late-onset sepsis (LOS), necrotizing enterocolitis (NEC), or death in the first 8 weeks of life in newborns with a birth weight <2,000 g. Methods: A retrospective cohort study was conducted, with the exposure being the consumption of mother's own LF and mother's own milk in the first 10 days of life, and the outcome being LOS, NEC, or death during days 11 and 56 of life, analyzed by Cox regression. Results: Two hundred and ninety-nine infants were enrolled, including 240 with human LF intake information. The average daily human LF intake over days 4-10 of life was 283 mg/kg/day (IQR 114-606 mg/kg/day). The hazard ratio (HR) of mother's own milk LF intake ≥100 mg/kg/day in days 4-10 for LOS, NEC, or death was 0.297 (95% CI 0.156-0.568, p < 0.001); the adjusted HR was 0.752 (95% CI 0.301-1.877, p = 0.541). The adjusted HR of mother's own milk cumulative intake (days 4-10) of 54-344 mL/kg (25-75 quartiles) for LOS, NEC, or death was 0.414 (95% CI 0.196-0.873, p = 0.02). Infants who developed an event (LOS, NEC, or death) had significantly less median daily human LF intake than those that did not (89 vs. 334 mg/kg/day, respectively, p < 0.0001). Conclusion: Consumption of higher amounts of mother's own milk in the first days of life is associated with less infection, NEC, and death. Early human milk intake should be strongly encouraged in all newborns. en_US
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartofseries Neonatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Breast milk en_US
dc.subject Lactoferrin en_US
dc.subject Sepsis en_US
dc.subject Infection en_US
dc.subject Neonates en_US
dc.subject Preterm en_US
dc.title Is mother's own milk lactoferrin intake associated with reduced neonatal sepsis, necrotizing enterocolitis, and death? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1159/000505663
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.relation.issn 1661-7819


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