Universidad Peruana Cayetano Heredia

Staining of antinuclear antibodies and antibodies against removable nuclear antigens in connective tissue diseases

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dc.contributor.author Oliva Menacho, J.E.
dc.contributor.author Arroyo-Acevedo, J.L.
dc.contributor.author Oliva-Candela, J.A.
dc.contributor.author García-Hjarles, M.A.
dc.contributor.author Domínguez-Huarcaya, L.
dc.date.accessioned 2020-12-14T16:10:01Z
dc.date.available 2020-12-14T16:10:01Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8751
dc.description.abstract Introduction and objectives: Connective tissue diseases are inflammatory, autoimmune diseases and threaten quality of life. To determine the relationship between staining patterns of antinuclear antibodies and antibodies against extractable nuclear antigens in patients with connective tissue disease. Materials and methods: Observational, basic, analytical and transversal study. Study conducted in the Immunology Service of the Arzobispo Loayza National Hospital between January 2017 and June 2017. We analyzed 291 samples of patients with CTD and for the detection of anti-nuclear antibody staining patterns, the immunological kit and observation with microscope of at 40X Immunofluorescence and for the detection of the antibodies against extractable nuclear antigens. The Immunoblot method was employed. Statistical analyses were carried out with the statistical package SPSS version 21 for Windows. We used the Pearson Chi-square test for the categorical variables, a value of p < 0.05 was considered significant. Results: There was a significant relationship p < 0.05 of the homogeneous pattern, the mottled pattern with Anti-histones (p = 0.000), Anti-nucleosomes (p = 0.000), Anti-Ro 52 (p = 0.000), Anti-SSA (p = 0.001), Anti-SSB (p = 0.003), Anti-dsDNA (p = 0.000) with the Pearson Chi-square test. There was a significant relationship of p < 0.05 of the centromeric pattern with Anti-Cenp B (p = 0.000) with Fisher⿿s exact statistic. Conclusions: There was a significant relationship between the anti-nuclear antibody staining patterns and the antibodies to the core extractable antigens in patients with systemic lupus erythematosus, Sjögren⿿s syndrome, Calcinosis, Raynaud⿿s phenomenon, esophageal Dysmotility, sclerodactyly and Telangiectasia (CREST), Scleroderma and Polymyositis. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Allergologia et Immunopathologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Antinuclear antibodies en_US
dc.subject antibodies against removable nuclear antigens en_US
dc.subject tissue diseases en_US
dc.title Staining of antinuclear antibodies and antibodies against removable nuclear antigens in connective tissue diseases en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.aller.2019.07.002
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.relation.issn 1578-1267


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