Universidad Peruana Cayetano Heredia

Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: Study protocol

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dc.contributor.author Osias, E.
dc.contributor.author Hung, P.
dc.contributor.author Giacani, L.
dc.contributor.author Stafylis, C.
dc.contributor.author Konda, K.A.
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Reyes-Díaz, E.M.
dc.contributor.author Comulada, W.S.
dc.contributor.author Haake, D.A.
dc.contributor.author Haynes, A.M.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, J.D.
dc.date.accessioned 2020-12-14T16:10:02Z
dc.date.available 2020-12-14T16:10:02Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8754
dc.description.abstract Background: The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives. Though our understanding of the pathogenesis of this disease and the biology of the syphilis agent, Treponema pallidum subsp. pallidum has improved over the last two decades, further research is necessary to improve clinical diagnosis and disease management protocols. Additionally, such research efforts could contribute to the identification of possible targets for the development of an effective vaccine to stem syphilis spread. Methods: This study will recruit two cohorts of participants with active syphilis infection, one with de novo infection, one with repeat infection. Whole blood specimens will be collected from each study participant at baseline, 4, 12, 24, 36, and 48 weeks, to track specific markers of their immunological response, as well as to compare humoral reactivity to Treponema pallidum antigens between the two groups. Additionally, we will use serum specimens to look for unique cytokine patterns in participants with early syphilis. Oral and blood samples, as well as samples from any syphilitic lesions present, will also be collected to sequence any Treponema pallidum DNA found. Discussion: By furthering our understanding of syphilis pathogenesis and human host immune response to Treponema pallidum, we will provide important data that will help in development of new point-of-care tests that could better identify active infection, leading to improved syphilis diagnosis and management. Findings could also contribute to vaccine development efforts. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Syphilis en_US
dc.subject Treponema pallidum en_US
dc.subject Peru en_US
dc.subject Cytokine profiling en_US
dc.subject Molecular typing en_US
dc.subject Vaccine development en_US
dc.title Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: Study protocol en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12879-020-05141-0
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1471-2334


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