Universidad Peruana Cayetano Heredia

Genomic epidemiology of campylobacter jejuni associated with asymptomatic pediatric infection in the peruvian amazon

Mostrar el registro sencillo del ítem

dc.contributor.author Pascoe, B.
dc.contributor.author Schiaffino Salazar, Francesca
dc.contributor.author Murray, S.
dc.contributor.author Méric, G.
dc.contributor.author Bayliss, S.C.
dc.contributor.author Hitchings, M.D.
dc.contributor.author Mourkas, E.
dc.contributor.author Calland, J.K.
dc.contributor.author Burga, R.
dc.contributor.author Yori, P.P.
dc.contributor.author Jolley, K.A.
dc.contributor.author Cooper, K.K.
dc.contributor.author Parker, C.T.
dc.contributor.author Olortegui, M.P.
dc.contributor.author Kosek, M.N.
dc.contributor.author Sheppard, S.K.
dc.date.accessioned 2020-12-14T16:10:02Z
dc.date.available 2020-12-14T16:10:02Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8756
dc.description.abstract Campylobacter is the leading bacterial cause of gastroenteritis worldwide and its incidence is especially high in low-and middle-income countries (LMIC). Disease epidemiology in LMICs is different compared to high income countries like the USA or in Europe. Children in LMICs commonly have repeated and chronic infections even in the absence of symptoms, which can lead to deficits in early childhood development. In this study, we sequenced and characterized C. jejuni (n = 62) from a longitudinal cohort study of children under the age of 5 with and without diarrheal symptoms, and contextualized them within a global C. jejuni genome collection. Epidemiological differences in disease presentation were reflected in the genomes, specifically by the absence of some of the most common global disease-causing lineages. As in many other countries, poultry-associated strains were likely a major source of human infection but almost half of local disease cases (15 of 31) were attributable to genotypes that are rare outside of Peru. Asymptomatic infection was not limited to a single (or few) human adapted lineages but resulted from phylogenetically divergent strains suggesting an important role for host factors in the cryptic epidemiology of campylobacterio-sis in LMICs. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Genomics en_US
dc.subject Low and middle income countries en_US
dc.subject Pediatrics en_US
dc.subject Campylobacter en_US
dc.subject Pediatric infections en_US
dc.subject Epidemiology en_US
dc.subject Bird genomics en_US
dc.subject Phylogeography en_US
dc.title Genomic epidemiology of campylobacter jejuni associated with asymptomatic pediatric infection in the peruvian amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0008533
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas