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Nox2 upregulation and p38α mapk activation in right ventricular hypertrophy of rats exposed to long-term chronic intermittent hypobaric hypoxia

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dc.contributor.author Pena, E.
dc.contributor.author Siques, P.
dc.contributor.author Brito, J.
dc.contributor.author Arribas, S.M.
dc.contributor.author Böger, R.
dc.contributor.author Hannemann, J.
dc.contributor.author León-Velarde, F.
dc.contributor.author González, M.C.
dc.contributor.author López, M.R.
dc.contributor.author de Pablo, Á.L.L.
dc.date.accessioned 2020-12-14T16:10:03Z
dc.date.available 2020-12-14T16:10:03Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8760
dc.description.abstract One of the consequences of high altitude (hypobaric hypoxia) exposure is the development of right ventricular hypertrophy (RVH). One particular type of exposure is long-term chronic intermittent hypobaric hypoxia (CIH); the molecular alterations in RVH in this particular condition are less known. Studies show an important role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex-induced oxidative stress and protein kinase activation in different models of cardiac hypertrophy. The aim was to determine the oxidative level, NADPH oxidase expression and MAPK activation in rats with RVH induced by CIH. Male Wistar rats were randomly subjected to CIH (2 days hypoxia/2 days normoxia; n = 10) and normoxia (NX; n = 10) for 30 days. Hypoxia was simulated with a hypobaric chamber. Measurements in the RV included the following: hypertrophy, Nox2, Nox4, p22phox, LOX-1 and HIF-1α expression, lipid peroxidation and H2 O2 concentration, and p38α and Akt activation. All CIH rats developed RVH and showed an upregulation of LOX-1, Nox2 and p22phox and an increase in lipid peroxidation, HIF-1α stabilization and p38α activation. Rats with long-term CIH-induced RVH clearly showed Nox2, p22phox and LOX-1 upregulation and increased lipid peroxidation, HIF-1α stabilization and p38α activation. Therefore, these molecules may be considered new targets in CIH-induced RVH. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof urn:issn:1422-0067
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Nox2 upregulation and p38α mapk activation in right ventricular hypertrophy of rats exposed to long-term chronic intermittent hypobaric hypoxia en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/ijms21228576
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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